229362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3415971..3416591 Replicon chromosome
Accession NZ_CP089792
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00816

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LUY16_RS16710 Protein ID WP_001280991.1
Coordinates 3416373..3416591 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LUY16_RS16705 Protein ID WP_000344807.1
Coordinates 3415971..3416345 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY16_RS16695 (3411110) 3411110..3412303 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LUY16_RS16700 (3412326) 3412326..3415475 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LUY16_RS16705 (3415971) 3415971..3416345 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LUY16_RS16710 (3416373) 3416373..3416591 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LUY16_RS16715 (3416770) 3416770..3417321 + 552 WP_001278793.1 maltose O-acetyltransferase -
LUY16_RS16720 (3417439) 3417439..3417909 + 471 WP_000136183.1 YlaC family protein -
LUY16_RS16725 (3417965) 3417965..3418105 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LUY16_RS16730 (3418111) 3418111..3418371 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LUY16_RS16735 (3418596) 3418596..3420146 + 1551 WP_000213145.1 EAL domain-containing protein -
LUY16_RS16745 (3420377) 3420377..3420766 + 390 WP_023224410.1 MGMT family protein -
LUY16_RS16750 (3420799) 3420799..3421368 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T229362 WP_001280991.1 NZ_CP089792:3416373-3416591 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T229362 NZ_CP124455:c4685705-4685598 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT229362 WP_000344807.1 NZ_CP089792:3415971-3416345 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT229362 NZ_CP124455:4685762-4685819 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References