Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4150876..4151519 Replicon chromosome
Accession NZ_CP089791
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag LUY13_RS20080 Protein ID WP_000048134.1
Coordinates 4151103..4151519 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag LUY13_RS20075 Protein ID WP_001261294.1
Coordinates 4150876..4151106 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY13_RS20065 (4147889) 4147889..4150027 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
LUY13_RS20070 (4150244) 4150244..4150708 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUY13_RS20075 (4150876) 4150876..4151106 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUY13_RS20080 (4151103) 4151103..4151519 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
LUY13_RS20085 (4151580) 4151580..4153493 - 1914 WP_001212148.1 BglG family transcription antiterminator -
LUY13_RS20090 (4153510) 4153510..4154250 - 741 WP_000779255.1 KDGP aldolase family protein -
LUY13_RS20095 (4154247) 4154247..4155365 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LUY13_RS20100 (4155349) 4155349..4156482 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T229345 WP_000048134.1 NZ_CP089791:4151103-4151519 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T229345 NZ_CP124455:425515-425865 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT229345 WP_001261294.1 NZ_CP089791:4150876-4151106 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT229345 NZ_CP124455:425270-425521 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References