Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3417966..3418586 Replicon chromosome
Accession NZ_CP089791
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LUY13_RS16730 Protein ID WP_001280991.1
Coordinates 3418368..3418586 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LUY13_RS16725 Protein ID WP_000344807.1
Coordinates 3417966..3418340 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY13_RS16715 (3413105) 3413105..3414298 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LUY13_RS16720 (3414321) 3414321..3417470 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LUY13_RS16725 (3417966) 3417966..3418340 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LUY13_RS16730 (3418368) 3418368..3418586 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LUY13_RS16735 (3418765) 3418765..3419316 + 552 WP_001278793.1 maltose O-acetyltransferase -
LUY13_RS16740 (3419434) 3419434..3419904 + 471 WP_000136183.1 YlaC family protein -
LUY13_RS16745 (3419960) 3419960..3420100 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LUY13_RS16750 (3420106) 3420106..3420366 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LUY13_RS16755 (3420591) 3420591..3422141 + 1551 WP_000213145.1 EAL domain-containing protein -
LUY13_RS16765 (3422372) 3422372..3422761 + 390 WP_023224410.1 MGMT family protein -
LUY13_RS16770 (3422794) 3422794..3423363 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T229341 WP_001280991.1 NZ_CP089791:3418368-3418586 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T229341 NZ_CP124443:c35390-35085 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT229341 WP_000344807.1 NZ_CP089791:3417966-3418340 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT229341 NZ_CP124443:c35610-35392 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References