229340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2427087..2427609 Replicon chromosome
Accession NZ_CP089791
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag LUY13_RS11855 Protein ID WP_000221345.1
Coordinates 2427325..2427609 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LUY13_RS11850 Protein ID WP_000885424.1
Coordinates 2427087..2427335 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY13_RS11820 (2422613) 2422613..2423521 - 909 WP_052939372.1 LysR family transcriptional regulator -
LUY13_RS11825 (2423923) 2423923..2424111 + 189 WP_001276021.1 DUF29 family protein -
LUY13_RS11830 (2424477) 2424477..2425216 + 740 Protein_2315 hypothetical protein -
LUY13_RS11835 (2425218) 2425218..2426126 - 909 WP_077906523.1 hypothetical protein -
LUY13_RS11840 (2426399) 2426399..2426730 - 332 Protein_2317 DUF1493 family protein -
LUY13_RS11845 (2426816) 2426816..2426935 - 120 Protein_2318 type II and III secretion system -
LUY13_RS11850 (2427087) 2427087..2427335 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LUY13_RS11855 (2427325) 2427325..2427609 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUY13_RS11860 (2427780) 2427780..2428169 + 390 WP_000194089.1 RidA family protein -
LUY13_RS11865 (2428221) 2428221..2429300 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LUY13_RS11870 (2429493) 2429493..2429981 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
LUY13_RS11875 (2430026) 2430026..2431534 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2419741..2434391 14650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T229340 WP_000221345.1 NZ_CP089791:2427325-2427609 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T229340 NZ_CP124442:c5054973-5054866 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT229340 WP_000885424.1 NZ_CP089791:2427087-2427335 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT229340 NZ_CP124442:5055021-5055087 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References