Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
| Location | 864271..864931 | Replicon | chromosome |
| Accession | NZ_CP089791 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820 | ||
Toxin (Protein)
| Gene name | cptA | Uniprot ID | Q57K70 |
| Locus tag | LUY13_RS04260 | Protein ID | WP_000244756.1 |
| Coordinates | 864518..864931 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | cptB | Uniprot ID | S5MU13 |
| Locus tag | LUY13_RS04255 | Protein ID | WP_000351186.1 |
| Coordinates | 864271..864537 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUY13_RS04235 (860200) | 860200..861633 | - | 1434 | WP_001230143.1 | 6-phospho-beta-glucosidase BglA | - |
| LUY13_RS04240 (861791) | 861791..862102 | + | 312 | WP_001182976.1 | N(4)-acetylcytidine aminohydrolase | - |
| LUY13_RS04245 (862266) | 862266..862925 | + | 660 | WP_000250289.1 | hemolysin III family protein | - |
| LUY13_RS04250 (863041) | 863041..864021 | - | 981 | WP_000874178.1 | tRNA-modifying protein YgfZ | - |
| LUY13_RS04255 (864271) | 864271..864537 | + | 267 | WP_000351186.1 | FAD assembly factor SdhE | Antitoxin |
| LUY13_RS04260 (864518) | 864518..864931 | + | 414 | WP_000244756.1 | protein YgfX | Toxin |
| LUY13_RS04265 (864984) | 864984..865505 | - | 522 | WP_001055885.1 | flavodoxin FldB | - |
| LUY13_RS04270 (865618) | 865618..866514 | + | 897 | WP_000434302.1 | site-specific tyrosine recombinase XerD | - |
| LUY13_RS04275 (866538) | 866538..867251 | + | 714 | WP_023223829.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
| LUY13_RS04280 (867257) | 867257..868990 | + | 1734 | WP_023223830.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 16183.15 Da Isoelectric Point: 10.7537
>T229330 WP_000244756.1 NZ_CP089791:864518-864931 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH
Download Length: 414 bp
>T229330 NZ_CP124442:c2620483-2620376 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10550.05 Da Isoelectric Point: 6.0783
>AT229330 WP_000351186.1 NZ_CP089791:864271-864537 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT229330 NZ_CP124442:2620532-2620597 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3Z1E9V5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I0YWH4 |