Detailed information of TA system TA022933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1571996..1572641
• Replicon: chromosome
• Accession: NC_010939
• Organism: Actinobacillus pleuropneumoniae serovar 7 str. AP76

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: APP7_RS07235
• Protein ID: WP_005619674.1
• Coordinates: 1572270..1572641 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: APP7_RS07230
• Protein ID: WP_005598477.1
• Coordinates: 1571996..1572289 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APP7_RS07200	1567328..1568011	-	684	WP_005605188.1	arginine ABC transporter permease ArtM	-
APP7_RS07205	1568011..1568682	-	672	WP_005617821.1	arginine ABC transporter permease ArtQ	-
APP7_RS07210	1568688..1569407	-	720	WP_012478527.1	transporter substrate-binding domain-containing protein	-
APP7_RS07215	1569427..1570161	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
APP7_RS07220	1570386..1570883	-	498	WP_005617825.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
APP7_RS07225	1570956..1571918	+	963	WP_012478528.1	calcium/sodium antiporter	-
APP7_RS07230	1571996..1572289	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
APP7_RS07235	1572270..1572641	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
APP7_RS07240	1572835..1574586	+	1752	WP_005617831.1	protein-disulfide reductase DsbD	-
APP7_RS07245	1574644..1575213	+	570	WP_005608594.1	elongation factor P hydroxylase	-
APP7_RS07250	1575257..1576111	-	855	WP_005615766.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T22933 WP_005619674.1 NC_010939:c1572641-1572270 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T22933 NC_010939:c1572641-1572270 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT22933 WP_005598477.1 NC_010939:c1572289-1571996 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT22933 NC_010939:c1572289-1571996 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATCTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206