Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
Location | 299190..299981 | Replicon | chromosome |
Accession | NZ_CP089791 | ||
Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820 |
Toxin (Protein)
Gene name | ataT | Uniprot ID | C0Q119 |
Locus tag | LUY13_RS01380 | Protein ID | WP_000369560.1 |
Coordinates | 299463..299981 (+) | Length | 173 a.a. |
Antitoxin (Protein)
Gene name | ataR | Uniprot ID | Q57IR1 |
Locus tag | LUY13_RS01375 | Protein ID | WP_001275017.1 |
Coordinates | 299190..299459 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LUY13_RS01355 (294771) | 294771..295439 | + | 669 | WP_000617729.1 | cell division ATP-binding protein FtsE | - |
LUY13_RS01360 (295432) | 295432..296487 | + | 1056 | WP_001081707.1 | permease-like cell division protein FtsX | - |
LUY13_RS01365 (296733) | 296733..297587 | + | 855 | WP_000159621.1 | RNA polymerase sigma factor RpoH | - |
LUY13_RS01370 (297909) | 297909..299012 | + | 1104 | WP_001533929.1 | branched chain amino acid ABC transporter substrate-binding protein LivJ | - |
LUY13_RS01375 (299190) | 299190..299459 | + | 270 | WP_001275017.1 | DUF1778 domain-containing protein | Antitoxin |
LUY13_RS01380 (299463) | 299463..299981 | + | 519 | WP_000369560.1 | GNAT family N-acetyltransferase | Toxin |
LUY13_RS01385 (299978) | 299978..300361 | - | 384 | WP_000778873.1 | aspartate 1-decarboxylase autocleavage activator PanM | - |
LUY13_RS01390 (300783) | 300783..301892 | + | 1110 | WP_023224165.1 | high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK | - |
LUY13_RS01395 (301952) | 301952..302878 | + | 927 | WP_000003005.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
LUY13_RS01400 (302875) | 302875..304152 | + | 1278 | WP_000803766.1 | branched chain amino acid ABC transporter permease LivM | - |
LUY13_RS01405 (304149) | 304149..304916 | + | 768 | WP_000082083.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 173 a.a. Molecular weight: 19414.16 Da Isoelectric Point: 8.9619
>T229329 WP_000369560.1 NZ_CP089791:299463-299981 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG
Download Length: 519 bp
>T229329 NZ_CP124442:c2620000-2619893 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10086.53 Da Isoelectric Point: 7.2056
>AT229329 WP_001275017.1 NZ_CP089791:299190-299459 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME
Download Length: 270 bp
>AT229329 NZ_CP124442:2620057-2620114 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5H5BA59 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5I8URP5 |