Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 299190..299981 Replicon chromosome
Accession NZ_CP089791
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00820

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag LUY13_RS01380 Protein ID WP_000369560.1
Coordinates 299463..299981 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag LUY13_RS01375 Protein ID WP_001275017.1
Coordinates 299190..299459 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY13_RS01355 (294771) 294771..295439 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
LUY13_RS01360 (295432) 295432..296487 + 1056 WP_001081707.1 permease-like cell division protein FtsX -
LUY13_RS01365 (296733) 296733..297587 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
LUY13_RS01370 (297909) 297909..299012 + 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LUY13_RS01375 (299190) 299190..299459 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
LUY13_RS01380 (299463) 299463..299981 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
LUY13_RS01385 (299978) 299978..300361 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
LUY13_RS01390 (300783) 300783..301892 + 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LUY13_RS01395 (301952) 301952..302878 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LUY13_RS01400 (302875) 302875..304152 + 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
LUY13_RS01405 (304149) 304149..304916 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T229329 WP_000369560.1 NZ_CP089791:299463-299981 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

>T229329 NZ_CP124442:c2620000-2619893 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT229329 WP_001275017.1 NZ_CP089791:299190-299459 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp

>AT229329 NZ_CP124442:2620057-2620114 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References