Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4151108..4151751 Replicon chromosome
Accession NZ_CP089790
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00830

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag LUY12_RS20070 Protein ID WP_000048134.1
Coordinates 4151335..4151751 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag LUY12_RS20065 Protein ID WP_001261294.1
Coordinates 4151108..4151338 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY12_RS20055 (4148121) 4148121..4150259 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
LUY12_RS20060 (4150476) 4150476..4150940 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUY12_RS20065 (4151108) 4151108..4151338 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUY12_RS20070 (4151335) 4151335..4151751 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
LUY12_RS20075 (4151812) 4151812..4153725 - 1914 WP_001212148.1 BglG family transcription antiterminator -
LUY12_RS20080 (4153742) 4153742..4154482 - 741 WP_000779255.1 KDGP aldolase family protein -
LUY12_RS20085 (4154479) 4154479..4155597 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LUY12_RS20090 (4155581) 4155581..4156714 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T229324 WP_000048134.1 NZ_CP089790:4151335-4151751 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T229324 NZ_CP124442:c1841441-1841034 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT229324 WP_001261294.1 NZ_CP089790:4151108-4151338 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT229324 NZ_CP124442:c1841688-1841422 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References