Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3417970..3418590 Replicon chromosome
Accession NZ_CP089790
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00830

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LUY12_RS16715 Protein ID WP_001280991.1
Coordinates 3418372..3418590 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LUY12_RS16710 Protein ID WP_000344807.1
Coordinates 3417970..3418344 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY12_RS16700 (3413109) 3413109..3414302 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LUY12_RS16705 (3414325) 3414325..3417474 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LUY12_RS16710 (3417970) 3417970..3418344 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LUY12_RS16715 (3418372) 3418372..3418590 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LUY12_RS16720 (3418769) 3418769..3419320 + 552 WP_001278793.1 maltose O-acetyltransferase -
LUY12_RS16725 (3419438) 3419438..3419908 + 471 WP_000136183.1 YlaC family protein -
LUY12_RS16730 (3419964) 3419964..3420104 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LUY12_RS16735 (3420110) 3420110..3420370 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LUY12_RS16740 (3420595) 3420595..3422145 + 1551 WP_000213145.1 EAL domain-containing protein -
LUY12_RS16750 (3422376) 3422376..3422765 + 390 WP_023224410.1 MGMT family protein -
LUY12_RS16755 (3422798) 3422798..3423367 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T229320 WP_001280991.1 NZ_CP089790:3418372-3418590 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T229320 NZ_CP124442:c560059-559957 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT229320 WP_000344807.1 NZ_CP089790:3417970-3418344 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT229320 NZ_CP124442:559956-560187 [Escherichia coli]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References