Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1486148..1486656 Replicon chromosome
Accession NC_010939
Organism Actinobacillus pleuropneumoniae serovar 7 str. AP76

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag APP7_RS06780 Protein ID WP_017357690.1
Coordinates 1486396..1486656 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag APP7_RS06775 Protein ID WP_017357689.1
Coordinates 1486148..1486399 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
APP7_RS06735 1481682..1482230 - 549 WP_005617759.1 type IV pilus biogenesis/stability protein PilW -
APP7_RS06740 1482284..1483466 - 1183 Protein_1323 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
APP7_RS06765 1484371..1485810 + 1440 WP_005605060.1 glutamate--tRNA ligase -
APP7_RS06775 1486148..1486399 + 252 WP_017357689.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
APP7_RS06780 1486396..1486656 + 261 WP_017357690.1 Txe/YoeB family addiction module toxin Toxin
APP7_RS06785 1486815..1486982 - 168 WP_005598320.1 Trm112 family protein -
APP7_RS06790 1486984..1487964 - 981 WP_005598322.1 tetraacyldisaccharide 4'-kinase -
APP7_RS06795 1488058..1489317 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
APP7_RS06800 1489317..1489907 - 591 WP_005601821.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
APP7_RS06805 1490029..1490421 + 393 WP_005620423.1 SufE family protein -
APP7_RS06820 1490780..1491553 - 774 WP_005618837.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.94 Da        Isoelectric Point: 8.0109

>T22932 WP_017357690.1 NC_010939:1486396-1486656 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
MKLTFSSNSWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

>T22932 NC_010939:1486396-1486656 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
ATGAAGCTAACTTTCTCGTCTAATTCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9336.62 Da        Isoelectric Point: 4.5659

>AT22932 WP_017357689.1 NC_010939:1486148-1486399 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
MQAITYTEARQNLAGTMSKVTEDFEPVLITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp

>AT22932 NC_010939:1486148-1486399 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATTTAGCAGGTACAATGTCAAAAGTAACAGAAGATTTTGAACCTGT
TTTAATTACAAGAAGCAAGGGTGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References