Detailed information of TA system TA022931

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 786208..786858
• Replicon: chromosome
• Accession: NC_010939
• Organism: Actinobacillus pleuropneumoniae serovar 7 str. AP76

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B0BNU3
• Locus tag: APP7_RS03585
• Protein ID: WP_005614926.1
• Coordinates: 786208..786597 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BNU4
• Locus tag: APP7_RS03590
• Protein ID: WP_005604117.1
• Coordinates: 786598..786858 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
APP7_RS03570	781863..783053	+	1191	WP_005617150.1	aspartate/tyrosine/aromatic aminotransferase	-
APP7_RS03575	783157..784440	-	1284	WP_005617151.1	Xaa-Pro aminopeptidase	-
APP7_RS03580	784849..786072	-	1224	WP_005617152.1	ATP-binding protein	-
APP7_RS03585	786208..786597	-	390	WP_005614926.1	type II toxin-antitoxin system VapC family toxin	Toxin
APP7_RS03590	786598..786858	-	261	WP_005604117.1	hypothetical protein	Antitoxin
APP7_RS03595	786992..789013	-	2022	WP_005617154.1	excinuclease ABC subunit B	-
APP7_RS03600	789190..790002	+	813	WP_005604121.1	EfeM/EfeO family lipoprotein	-
APP7_RS03605	790014..791207	+	1194	WP_005604123.1	deferrochelatase/peroxidase EfeB	-
APP7_RS03610	791218..791838	+	621	WP_005617156.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14837.17 Da
• Isoelectric Point: 5.1295

>T22931 WP_005614926.1 NC_010939:c786597-786208 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQFIPNLVLENWWK

Nucleotide

• Length: 390 bp

>T22931 NC_010939:c786597-786208 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGATCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGCGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCTGCGATTACGGTGATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGAAGGCAAAATCATGGGCGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TGTTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10289.63 Da
• Isoelectric Point: 5.1867

>AT22931 WP_005604117.1 NC_010939:c786858-786598 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Nucleotide

• Length: 261 bp

>AT22931 NC_010939:c786858-786598 [Actinobacillus pleuropneumoniae serovar 7 str. AP76]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAACAAGAACGCAAGCAAGAAATGGCAACTCGA
GATCCGTTCGAGGGCTTTTAA

Structures

Toxin

• AlphaFold DB: A3N029

Antitoxin

• AlphaFold DB: A3N030