Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 299192..299983 Replicon chromosome
Accession NZ_CP089790
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00830

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag LUY12_RS01385 Protein ID WP_000369560.1
Coordinates 299465..299983 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag LUY12_RS01380 Protein ID WP_001275017.1
Coordinates 299192..299461 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY12_RS01360 (294773) 294773..295441 + 669 WP_000617729.1 cell division ATP-binding protein FtsE -
LUY12_RS01365 (295434) 295434..296489 + 1056 WP_001081707.1 permease-like cell division protein FtsX -
LUY12_RS01370 (296735) 296735..297589 + 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
LUY12_RS01375 (297911) 297911..299014 + 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LUY12_RS01380 (299192) 299192..299461 + 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
LUY12_RS01385 (299465) 299465..299983 + 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
LUY12_RS01390 (299980) 299980..300363 - 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
LUY12_RS01395 (300785) 300785..301894 + 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LUY12_RS01400 (301954) 301954..302880 + 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LUY12_RS01405 (302877) 302877..304154 + 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
LUY12_RS01410 (304151) 304151..304918 + 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T229308 WP_000369560.1 NZ_CP089790:299465-299983 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

>T229308 NZ_CP124436:3484651-3485001 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT229308 WP_001275017.1 NZ_CP089790:299192-299461 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp

>AT229308 NZ_CP124436:3484406-3484657 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References