229304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4290547..4291328 Replicon chromosome
Accession NZ_CP089789
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00831

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag LUY20_RS20810 Protein ID WP_000625911.1
Coordinates 4290547..4291038 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag LUY20_RS20815 Protein ID WP_001271379.1
Coordinates 4291035..4291328 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY20_RS20785 (4285683) 4285683..4288121 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
LUY20_RS20790 (4288131) 4288131..4288670 - 540 WP_000721295.1 type 1 fimbrial protein -
LUY20_RS20795 (4288705) 4288705..4288995 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
LUY20_RS20800 (4289582) 4289582..4289809 + 228 WP_001112992.1 hypothetical protein -
LUY20_RS20805 (4290084) 4290084..4290332 - 249 Protein_4070 IS481 family transposase -
LUY20_RS20810 (4290547) 4290547..4291038 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
LUY20_RS20815 (4291035) 4291035..4291328 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
LUY20_RS20820 (4291646) 4291646..4291867 + 222 WP_052939504.1 hypothetical protein -
LUY20_RS20825 (4292131) 4292131..4293006 + 876 WP_023205266.1 AraC family transcriptional regulator -
LUY20_RS20830 (4293003) 4293003..4293290 + 288 WP_072103482.1 transcriptional regulator RtsB -
LUY20_RS20835 (4293283) 4293283..4293465 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
LUY20_RS20840 (4293485) 4293485..4293584 + 100 Protein_4077 hypothetical protein -
LUY20_RS20845 (4293632) 4293632..4293826 + 195 WP_223163373.1 hypothetical protein -
LUY20_RS20850 (4294121) 4294121..4295026 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4277525..4293465 15940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T229304 WP_000625911.1 NZ_CP089789:c4291038-4290547 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T229304 NZ_CP124436:c2618714-2618607 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT229304 WP_001271379.1 NZ_CP089789:c4291328-4291035 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT229304 NZ_CP124436:2618771-2618828 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References