Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3419228..3419848 Replicon chromosome
Accession NZ_CP089789
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00831

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LUY20_RS16720 Protein ID WP_001280991.1
Coordinates 3419630..3419848 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LUY20_RS16715 Protein ID WP_000344807.1
Coordinates 3419228..3419602 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY20_RS16705 (3414368) 3414368..3415561 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LUY20_RS16710 (3415584) 3415584..3418733 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LUY20_RS16715 (3419228) 3419228..3419602 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LUY20_RS16720 (3419630) 3419630..3419848 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LUY20_RS16725 (3420027) 3420027..3420578 + 552 WP_001278793.1 maltose O-acetyltransferase -
LUY20_RS16730 (3420696) 3420696..3421166 + 471 WP_000136183.1 YlaC family protein -
LUY20_RS16735 (3421222) 3421222..3421362 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LUY20_RS16740 (3421368) 3421368..3421628 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LUY20_RS16745 (3421853) 3421853..3423403 + 1551 WP_000213145.1 EAL domain-containing protein -
LUY20_RS16755 (3423634) 3423634..3424023 + 390 WP_023224410.1 MGMT family protein -
LUY20_RS16760 (3424056) 3424056..3424625 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T229299 WP_001280991.1 NZ_CP089789:3419630-3419848 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T229299 NZ_CP124436:c1840932-1840525 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT229299 WP_000344807.1 NZ_CP089789:3419228-3419602 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT229299 NZ_CP124436:c1841179-1840913 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References