Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2428337..2428859 Replicon chromosome
Accession NZ_CP089789
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00831

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag LUY20_RS11845 Protein ID WP_000221345.1
Coordinates 2428575..2428859 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LUY20_RS11840 Protein ID WP_000885424.1
Coordinates 2428337..2428585 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY20_RS11810 (2423863) 2423863..2424771 - 909 WP_052939372.1 LysR family transcriptional regulator -
LUY20_RS11815 (2425173) 2425173..2425361 + 189 WP_001276021.1 DUF29 family protein -
LUY20_RS11820 (2425727) 2425727..2426466 + 740 Protein_2314 hypothetical protein -
LUY20_RS11825 (2426468) 2426468..2427376 - 909 WP_077906523.1 hypothetical protein -
LUY20_RS11830 (2427649) 2427649..2427980 - 332 Protein_2316 DUF1493 family protein -
LUY20_RS11835 (2428066) 2428066..2428185 - 120 Protein_2317 type II and III secretion system -
LUY20_RS11840 (2428337) 2428337..2428585 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LUY20_RS11845 (2428575) 2428575..2428859 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LUY20_RS11850 (2429030) 2429030..2429419 + 390 WP_000194089.1 RidA family protein -
LUY20_RS11855 (2429471) 2429471..2430550 - 1080 WP_232689041.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LUY20_RS11860 (2430743) 2430743..2431231 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
LUY20_RS11865 (2431276) 2431276..2432784 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2420991..2435641 14650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T229298 WP_000221345.1 NZ_CP089789:2428575-2428859 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T229298 NZ_CP124436:c879375-879124 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT229298 WP_000885424.1 NZ_CP089789:2428337-2428585 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT229298 NZ_CP124436:c879127-878873 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References