Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1032796..1033610 | Replicon | chromosome |
| Accession | NZ_CP089789 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00831 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3G3DUX8 |
| Locus tag | LUY20_RS05030 | Protein ID | WP_000971653.1 |
| Coordinates | 1032796..1033323 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | LUY20_RS05035 | Protein ID | WP_000855694.1 |
| Coordinates | 1033320..1033610 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUY20_RS05000 (1029170) | 1029170..1029568 | + | 399 | Protein_981 | cytoplasmic protein | - |
| LUY20_RS05005 (1029779) | 1029779..1029997 | + | 219 | Protein_982 | hypothetical protein | - |
| LUY20_RS05010 (1030154) | 1030154..1030822 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| LUY20_RS05015 (1030849) | 1030849..1031343 | + | 495 | WP_000424946.1 | hypothetical protein | - |
| LUY20_RS05020 (1031515) | 1031515..1032171 | - | 657 | WP_023225036.1 | protein-serine/threonine phosphatase | - |
| LUY20_RS05025 (1032521) | 1032521..1032723 | + | 203 | Protein_986 | IS5/IS1182 family transposase | - |
| LUY20_RS05030 (1032796) | 1032796..1033323 | - | 528 | WP_000971653.1 | GNAT family N-acetyltransferase | Toxin |
| LUY20_RS05035 (1033320) | 1033320..1033610 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| LUY20_RS05040 (1033881) | 1033881..1034081 | - | 201 | Protein_989 | transposase | - |
| LUY20_RS05045 (1034322) | 1034322..1034648 | + | 327 | WP_000393295.1 | hypothetical protein | - |
| LUY20_RS05050 (1034921) | 1034921..1035268 | - | 348 | WP_001555786.1 | DUF1493 family protein | - |
| LUY20_RS05055 (1035253) | 1035253..1035702 | - | 450 | WP_023225038.1 | hypothetical protein | - |
| LUY20_RS05060 (1036134) | 1036134..1036577 | - | 444 | WP_023225039.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| LUY20_RS05065 (1037035) | 1037035..1037685 | + | 651 | WP_072203970.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | invH / invF / invG / invE / invA / invB | 1032547..1042998 | 10451 | |
| - | inside | IScluster/Tn | - | - | 1032547..1034081 | 1534 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19043.87 Da Isoelectric Point: 9.7032
>T229289 WP_000971653.1 NZ_CP089789:c1033323-1032796 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T229289 NZ_CP124429:4944237-4944548 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT229289 WP_000855694.1 NZ_CP089789:c1033610-1033320 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT229289 NZ_CP124429:4944549-4944839 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3DUX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |