229284

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4586588..4587379 Replicon chromosome
Accession NZ_CP089788
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag LUY19_RS22230 Protein ID WP_000369560.1
Coordinates 4586588..4587106 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag LUY19_RS22235 Protein ID WP_001275017.1
Coordinates 4587110..4587379 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY19_RS22205 (4581653) 4581653..4582420 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LUY19_RS22210 (4582417) 4582417..4583694 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
LUY19_RS22215 (4583691) 4583691..4584617 - 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LUY19_RS22220 (4584677) 4584677..4585786 - 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
LUY19_RS22225 (4586208) 4586208..4586591 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
LUY19_RS22230 (4586588) 4586588..4587106 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
LUY19_RS22235 (4587110) 4587110..4587379 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
LUY19_RS22240 (4587557) 4587557..4588660 - 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
LUY19_RS22245 (4588982) 4588982..4589836 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
LUY19_RS22250 (4590082) 4590082..4591137 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
LUY19_RS22255 (4591130) 4591130..4591798 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T229284 WP_000369560.1 NZ_CP089788:c4587106-4586588 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

>T229284 NZ_CP124429:c4090627-4090313 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT229284 WP_001275017.1 NZ_CP089788:c4587379-4587110 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp

>AT229284 NZ_CP124429:c4090316-4089900 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References