Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3852958..3853772 Replicon chromosome
Accession NZ_CP089788
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag LUY19_RS18580 Protein ID WP_000971653.1
Coordinates 3853245..3853772 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag LUY19_RS18575 Protein ID WP_000855694.1
Coordinates 3852958..3853248 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY19_RS18545 (3848883) 3848883..3849533 - 651 WP_072203970.1 type III secretion system transcriptional activator InvF -
LUY19_RS18550 (3849991) 3849991..3850434 + 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LUY19_RS18555 (3850866) 3850866..3851315 + 450 WP_023225038.1 hypothetical protein -
LUY19_RS18560 (3851300) 3851300..3851647 + 348 WP_001555786.1 DUF1493 family protein -
LUY19_RS18565 (3851920) 3851920..3852246 - 327 WP_000393295.1 hypothetical protein -
LUY19_RS18570 (3852487) 3852487..3852687 + 201 Protein_3613 transposase -
LUY19_RS18575 (3852958) 3852958..3853248 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
LUY19_RS18580 (3853245) 3853245..3853772 + 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
LUY19_RS18585 (3853845) 3853845..3854047 - 203 Protein_3616 IS5/IS1182 family transposase -
LUY19_RS18590 (3854397) 3854397..3855053 + 657 WP_023225036.1 protein-serine/threonine phosphatase -
LUY19_RS18595 (3855225) 3855225..3855719 - 495 WP_000424946.1 hypothetical protein -
LUY19_RS18600 (3855746) 3855746..3856414 - 669 WP_000445914.1 hypothetical protein -
LUY19_RS18605 (3856571) 3856571..3856789 - 219 Protein_3620 hypothetical protein -
LUY19_RS18610 (3857000) 3857000..3857398 - 399 Protein_3621 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3852487..3854021 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T229282 WP_000971653.1 NZ_CP089788:3853245-3853772 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T229282 NZ_CP124429:c3766666-3766259 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT229282 WP_000855694.1 NZ_CP089788:3852958-3853248 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT229282 NZ_CP124429:c3766913-3766647 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References