Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1466890..1467510 Replicon chromosome
Accession NZ_CP089788
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LUY19_RS06880 Protein ID WP_001280991.1
Coordinates 1466890..1467108 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LUY19_RS06885 Protein ID WP_000344807.1
Coordinates 1467136..1467510 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY19_RS06840 (1462113) 1462113..1462682 + 570 WP_000779802.1 YbaY family lipoprotein -
LUY19_RS06845 (1462715) 1462715..1463104 - 390 WP_023224410.1 MGMT family protein -
LUY19_RS06855 (1463335) 1463335..1464885 - 1551 WP_000213145.1 EAL domain-containing protein -
LUY19_RS06860 (1465110) 1465110..1465370 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LUY19_RS06865 (1465376) 1465376..1465516 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LUY19_RS06870 (1465572) 1465572..1466042 - 471 WP_000136183.1 YlaC family protein -
LUY19_RS06875 (1466160) 1466160..1466711 - 552 WP_001278793.1 maltose O-acetyltransferase -
LUY19_RS06880 (1466890) 1466890..1467108 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LUY19_RS06885 (1467136) 1467136..1467510 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LUY19_RS06890 (1468006) 1468006..1471155 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LUY19_RS06895 (1471178) 1471178..1472371 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T229272 WP_001280991.1 NZ_CP089788:c1467108-1466890 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T229272 NZ_CP124429:702480-702764 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT229272 WP_000344807.1 NZ_CP089788:c1467510-1467136 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT229272 NZ_CP124429:702244-702477 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References