Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpIK/PemK(toxin) |
Location | 3186177..3186756 | Replicon | chromosome |
Accession | NC_010842 | ||
Organism | Leptospira biflexa serovar Patoc strain Patoc 1 (Ames) |
Toxin (Protein)
Gene name | chpK | Uniprot ID | B0SPM6 |
Locus tag | LBF_RS15040 | Protein ID | WP_012389990.1 |
Coordinates | 3186177..3186521 (-) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | chpI | Uniprot ID | B0SPM7 |
Locus tag | LBF_RS15045 | Protein ID | WP_012389991.1 |
Coordinates | 3186508..3186756 (-) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LBF_RS15020 | 3181857..3183041 | + | 1185 | WP_012389985.1 | hypothetical protein | - |
LBF_RS15025 | 3183495..3184193 | + | 699 | WP_012389987.1 | class I SAM-dependent methyltransferase | - |
LBF_RS15030 | 3184533..3185102 | - | 570 | WP_012389988.1 | hypothetical protein | - |
LBF_RS15035 | 3185173..3186105 | - | 933 | WP_012389989.1 | hypothetical protein | - |
LBF_RS15040 | 3186177..3186521 | - | 345 | WP_012389990.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
LBF_RS15045 | 3186508..3186756 | - | 249 | WP_012389991.1 | hypothetical protein | Antitoxin |
LBF_RS15050 | 3186948..3187835 | - | 888 | WP_012389992.1 | ankyrin repeat domain-containing protein | - |
LBF_RS15055 | 3188218..3189039 | - | 822 | WP_012389993.1 | ankyrin repeat domain-containing protein | - |
LBF_RS15060 | 3189164..3189967 | - | 804 | WP_012389994.1 | hypothetical protein | - |
LBF_RS19080 | 3189984..3190160 | - | 177 | WP_167530803.1 | hypothetical protein | - |
LBF_RS15070 | 3190526..3191164 | + | 639 | WP_012389996.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12853.94 Da Isoelectric Point: 9.8443
>T22927 WP_012389990.1 NC_010842:c3186521-3186177 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
MTRGEIWWVDLGIPFGSEPGFQRPVLIVQNNAFNHSNINTIIVVPLTTNLHLATAPGNSMLKKEDTNLSKDSIVNVSQIV
TIDRERFIKKVTEIKNKHMKKVEEGMKLVLSLES
MTRGEIWWVDLGIPFGSEPGFQRPVLIVQNNAFNHSNINTIIVVPLTTNLHLATAPGNSMLKKEDTNLSKDSIVNVSQIV
TIDRERFIKKVTEIKNKHMKKVEEGMKLVLSLES
Download Length: 345 bp
>T22927 NC_010842:c3186521-3186177 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
ATGACACGTGGTGAAATCTGGTGGGTTGACCTTGGGATTCCATTTGGAAGTGAACCTGGATTCCAAAGACCAGTTTTAAT
CGTTCAAAATAATGCCTTTAATCATAGTAATATTAACACCATCATCGTTGTTCCATTGACCACGAACTTGCATTTAGCAA
CGGCACCAGGCAATTCAATGTTAAAAAAGGAAGATACAAATCTTTCCAAAGATTCAATTGTCAATGTCTCACAAATTGTA
ACCATTGATCGAGAACGCTTCATCAAAAAGGTAACAGAAATTAAAAACAAACATATGAAAAAAGTGGAAGAAGGGATGAA
ATTAGTTCTTTCTTTGGAATCTTGA
ATGACACGTGGTGAAATCTGGTGGGTTGACCTTGGGATTCCATTTGGAAGTGAACCTGGATTCCAAAGACCAGTTTTAAT
CGTTCAAAATAATGCCTTTAATCATAGTAATATTAACACCATCATCGTTGTTCCATTGACCACGAACTTGCATTTAGCAA
CGGCACCAGGCAATTCAATGTTAAAAAAGGAAGATACAAATCTTTCCAAAGATTCAATTGTCAATGTCTCACAAATTGTA
ACCATTGATCGAGAACGCTTCATCAAAAAGGTAACAGAAATTAAAAACAAACATATGAAAAAAGTGGAAGAAGGGATGAA
ATTAGTTCTTTCTTTGGAATCTTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9116.35 Da Isoelectric Point: 8.6015
>AT22927 WP_012389991.1 NC_010842:c3186756-3186508 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
MKTAVSIPDDLFVSAEKTAKKLGIPRSQLFALALEEFIQNHSNESITDSLNKVYTKSTKETETLASSLSVATLRRSLKND
TW
MKTAVSIPDDLFVSAEKTAKKLGIPRSQLFALALEEFIQNHSNESITDSLNKVYTKSTKETETLASSLSVATLRRSLKND
TW
Download Length: 249 bp
>AT22927 NC_010842:c3186756-3186508 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
ATGAAAACTGCGGTATCAATTCCAGACGATCTTTTTGTATCTGCGGAAAAAACAGCAAAAAAATTAGGTATTCCCAGAAG
TCAGTTGTTTGCACTCGCGCTTGAAGAATTCATTCAAAACCATTCCAATGAAAGCATAACAGATAGTTTAAACAAAGTGT
ATACAAAATCGACAAAAGAAACAGAAACTTTGGCATCGAGTCTCTCTGTCGCCACCTTACGAAGAAGTCTAAAAAATGAC
ACGTGGTGA
ATGAAAACTGCGGTATCAATTCCAGACGATCTTTTTGTATCTGCGGAAAAAACAGCAAAAAAATTAGGTATTCCCAGAAG
TCAGTTGTTTGCACTCGCGCTTGAAGAATTCATTCAAAACCATTCCAATGAAAGCATAACAGATAGTTTAAACAAAGTGT
ATACAAAATCGACAAAAGAAACAGAAACTTTGGCATCGAGTCTCTCTGTCGCCACCTTACGAAGAAGTCTAAAAAATGAC
ACGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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