Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 3186177..3186756 Replicon chromosome
Accession NC_010842
Organism Leptospira biflexa serovar Patoc strain Patoc 1 (Ames)

Toxin (Protein)


Gene name chpK Uniprot ID B0SPM6
Locus tag LBF_RS15040 Protein ID WP_012389990.1
Coordinates 3186177..3186521 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID B0SPM7
Locus tag LBF_RS15045 Protein ID WP_012389991.1
Coordinates 3186508..3186756 (-) Length 83 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBF_RS15020 3181857..3183041 + 1185 WP_012389985.1 hypothetical protein -
LBF_RS15025 3183495..3184193 + 699 WP_012389987.1 class I SAM-dependent methyltransferase -
LBF_RS15030 3184533..3185102 - 570 WP_012389988.1 hypothetical protein -
LBF_RS15035 3185173..3186105 - 933 WP_012389989.1 hypothetical protein -
LBF_RS15040 3186177..3186521 - 345 WP_012389990.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LBF_RS15045 3186508..3186756 - 249 WP_012389991.1 hypothetical protein Antitoxin
LBF_RS15050 3186948..3187835 - 888 WP_012389992.1 ankyrin repeat domain-containing protein -
LBF_RS15055 3188218..3189039 - 822 WP_012389993.1 ankyrin repeat domain-containing protein -
LBF_RS15060 3189164..3189967 - 804 WP_012389994.1 hypothetical protein -
LBF_RS19080 3189984..3190160 - 177 WP_167530803.1 hypothetical protein -
LBF_RS15070 3190526..3191164 + 639 WP_012389996.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 115 a.a.        Molecular weight: 12853.94 Da        Isoelectric Point: 9.8443

>T22927 WP_012389990.1 NC_010842:c3186521-3186177 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
MTRGEIWWVDLGIPFGSEPGFQRPVLIVQNNAFNHSNINTIIVVPLTTNLHLATAPGNSMLKKEDTNLSKDSIVNVSQIV
TIDRERFIKKVTEIKNKHMKKVEEGMKLVLSLES

Download         Length: 345 bp

>T22927 NC_010842:c3186521-3186177 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
ATGACACGTGGTGAAATCTGGTGGGTTGACCTTGGGATTCCATTTGGAAGTGAACCTGGATTCCAAAGACCAGTTTTAAT
CGTTCAAAATAATGCCTTTAATCATAGTAATATTAACACCATCATCGTTGTTCCATTGACCACGAACTTGCATTTAGCAA
CGGCACCAGGCAATTCAATGTTAAAAAAGGAAGATACAAATCTTTCCAAAGATTCAATTGTCAATGTCTCACAAATTGTA
ACCATTGATCGAGAACGCTTCATCAAAAAGGTAACAGAAATTAAAAACAAACATATGAAAAAAGTGGAAGAAGGGATGAA
ATTAGTTCTTTCTTTGGAATCTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9116.35 Da        Isoelectric Point: 8.6015

>AT22927 WP_012389991.1 NC_010842:c3186756-3186508 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
MKTAVSIPDDLFVSAEKTAKKLGIPRSQLFALALEEFIQNHSNESITDSLNKVYTKSTKETETLASSLSVATLRRSLKND
TW

Download         Length: 249 bp

>AT22927 NC_010842:c3186756-3186508 [Leptospira biflexa serovar Patoc strain 'Patoc 1 (Ames)']
ATGAAAACTGCGGTATCAATTCCAGACGATCTTTTTGTATCTGCGGAAAAAACAGCAAAAAAATTAGGTATTCCCAGAAG
TCAGTTGTTTGCACTCGCGCTTGAAGAATTCATTCAAAACCATTCCAATGAAAGCATAACAGATAGTTTAAACAAAGTGT
ATACAAAATCGACAAAAGAAACAGAAACTTTGGCATCGAGTCTCTCTGTCGCCACCTTACGAAGAAGTCTAAAAAATGAC
ACGTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B0SPM6


Antitoxin

Source ID Structure
AlphaFold DB B0SPM7

References