229268

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 733724..734367 Replicon chromosome
Accession NZ_CP089788
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag LUY19_RS03515 Protein ID WP_000048134.1
Coordinates 733724..734140 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag LUY19_RS03520 Protein ID WP_001261294.1
Coordinates 734137..734367 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY19_RS03495 (728761) 728761..729894 + 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -
LUY19_RS03500 (729878) 729878..730996 + 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LUY19_RS03505 (730993) 730993..731733 + 741 WP_000779255.1 KDGP aldolase family protein -
LUY19_RS03510 (731750) 731750..733663 + 1914 WP_001212148.1 BglG family transcription antiterminator -
LUY19_RS03515 (733724) 733724..734140 - 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
LUY19_RS03520 (734137) 734137..734367 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LUY19_RS03525 (734535) 734535..734999 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LUY19_RS03530 (735216) 735216..737354 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T229268 WP_000048134.1 NZ_CP089788:c734140-733724 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T229268 NZ_CP124429:332058-332231 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT229268 WP_001261294.1 NZ_CP089788:c734367-734137 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT229268 NZ_CP124429:331734-332030 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References