Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 595400..596181 | Replicon | chromosome |
| Accession | NZ_CP089788 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A3G3E5T9 |
| Locus tag | LUY19_RS02785 | Protein ID | WP_000625911.1 |
| Coordinates | 595690..596181 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | V7IUD2 |
| Locus tag | LUY19_RS02780 | Protein ID | WP_001271379.1 |
| Coordinates | 595400..595693 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LUY19_RS02745 (591700) | 591700..592605 | + | 906 | WP_001268192.1 | YjiK family protein | - |
| LUY19_RS02750 (592900) | 592900..593094 | - | 195 | WP_223163373.1 | hypothetical protein | - |
| LUY19_RS02755 (593142) | 593142..593241 | - | 100 | Protein_522 | hypothetical protein | - |
| LUY19_RS02760 (593261) | 593261..593443 | + | 183 | WP_072106065.1 | ATP-binding cassette domain-containing protein | - |
| LUY19_RS02765 (593436) | 593436..593723 | - | 288 | WP_072103482.1 | transcriptional regulator RtsB | - |
| LUY19_RS02770 (593720) | 593720..594595 | - | 876 | WP_023205266.1 | AraC family transcriptional regulator | - |
| LUY19_RS02775 (594861) | 594861..595082 | - | 222 | WP_052939504.1 | hypothetical protein | - |
| LUY19_RS02780 (595400) | 595400..595693 | + | 294 | WP_001271379.1 | DUF1778 domain-containing protein | Antitoxin |
| LUY19_RS02785 (595690) | 595690..596181 | + | 492 | WP_000625911.1 | GNAT family N-acetyltransferase | Toxin |
| LUY19_RS02790 (596396) | 596396..596644 | + | 249 | Protein_529 | IS481 family transposase | - |
| LUY19_RS02795 (596919) | 596919..597146 | - | 228 | WP_001112992.1 | hypothetical protein | - |
| LUY19_RS02800 (597733) | 597733..598023 | + | 291 | WP_000773469.1 | PapB/FocB family fimbrial expression transcriptional regulator | - |
| LUY19_RS02805 (598058) | 598058..598597 | + | 540 | WP_000721295.1 | type 1 fimbrial protein | - |
| LUY19_RS02810 (598607) | 598607..601045 | + | 2439 | WP_023224120.1 | F4 (K88) fimbrial usher FaeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | faeC / faeD / faeE / faeF / faeH / faeI | 593436..609203 | 15767 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17663.44 Da Isoelectric Point: 7.2655
>T229267 WP_000625911.1 NZ_CP089788:595690-596181 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T229267 NZ_CP124425:95923-96303 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10938.54 Da Isoelectric Point: 9.8590
>AT229267 WP_001271379.1 NZ_CP089788:595400-595693 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT229267 NZ_CP124425:95702-95923 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3E5T9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V7IUD2 |