Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2917277..2917991 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag LVJ76_RS13690 Protein ID WP_003413460.1
Coordinates 2917551..2917991 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag LVJ76_RS13685 Protein ID WP_003413456.1
Coordinates 2917277..2917564 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS13650 (LVJ76_13660) 2912699..2912944 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LVJ76_RS13655 (LVJ76_13665) 2912941..2913345 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
LVJ76_RS13660 (LVJ76_13670) 2913562..2914182 + 621 WP_003413441.1 DUF4178 domain-containing protein -
LVJ76_RS13665 (LVJ76_13675) 2914193..2914687 + 495 WP_003413444.1 DUF2617 family protein -
LVJ76_RS13670 (LVJ76_13680) 2914684..2915115 + 432 WP_003899390.1 DUF4247 domain-containing protein -
LVJ76_RS13675 (LVJ76_13685) 2915140..2915598 + 459 WP_003413451.1 DUF350 domain-containing protein -
LVJ76_RS13680 (LVJ76_13690) 2915595..2917166 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
LVJ76_RS13685 (LVJ76_13695) 2917277..2917564 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
LVJ76_RS13690 (LVJ76_13700) 2917551..2917991 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ76_RS13695 (LVJ76_13705) 2918012..2918767 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
LVJ76_RS13700 (LVJ76_13710) 2918900..2919496 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
LVJ76_RS13705 (LVJ76_13715) 2919504..2920349 - 846 WP_003413466.1 acyl-CoA thioesterase II -
LVJ76_RS13710 (LVJ76_13720) 2920378..2921277 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
LVJ76_RS13715 (LVJ76_13725) 2921405..2922079 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T229251 WP_003413460.1 NZ_CP089781:2917551-2917991 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T229251 NZ_CP124424:2051462-2051926 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT229251 WP_003413456.1 NZ_CP089781:2917277-2917564 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT229251 NZ_CP124424:2051127-2051462 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References