Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 2856935..2857572 | Replicon | chromosome |
| Accession | NZ_CP089781 | ||
| Organism | Mycobacterium tuberculosis strain 02-R1179 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P0DMV7 |
| Locus tag | LVJ76_RS13425 | Protein ID | WP_003413180.1 |
| Coordinates | 2856935..2857330 (-) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P9WJ44 |
| Locus tag | LVJ76_RS13430 | Protein ID | WP_003413183.1 |
| Coordinates | 2857327..2857572 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ76_RS13385 (LVJ76_13395) | 2852338..2853549 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| LVJ76_RS13390 (LVJ76_13400) | 2853676..2854335 | + | 660 | WP_014585545.1 | LppA family lipoprotein | - |
| LVJ76_RS13395 (LVJ76_13405) | 2854332..2854994 | + | 663 | WP_003900848.1 | LppA family lipoprotein | - |
| LVJ76_RS13400 (LVJ76_13410) | 2854991..2855269 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| LVJ76_RS13405 (LVJ76_13415) | 2855362..2855775 | + | 414 | WP_003413164.1 | PIN domain nuclease | - |
| LVJ76_RS13410 (LVJ76_13420) | 2855814..2856071 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | - |
| LVJ76_RS13415 (LVJ76_13425) | 2856068..2856445 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ76_RS13420 (LVJ76_13430) | 2856461..2856835 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| LVJ76_RS13425 (LVJ76_13435) | 2856935..2857330 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | Toxin |
| LVJ76_RS13430 (LVJ76_13440) | 2857327..2857572 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | Antitoxin |
| LVJ76_RS13435 (LVJ76_13445) | 2857983..2858402 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| LVJ76_RS13440 (LVJ76_13450) | 2858414..2859223 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| LVJ76_RS13445 (LVJ76_13455) | 2859220..2860473 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| LVJ76_RS13450 (LVJ76_13460) | 2860466..2860978 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14619.53 Da Isoelectric Point: 6.9794
>T229250 WP_003413180.1 NZ_CP089781:c2857330-2856935 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE
Download Length: 396 bp
>T229250 NZ_CP124424:c2010146-2009832 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9098.33 Da Isoelectric Point: 5.6007
>AT229250 WP_003413183.1 NZ_CP089781:c2857572-2857327 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E
Download Length: 246 bp
>AT229250 NZ_CP124424:c2009835-2009419 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 5WZ4 | |
| PDB | 5WZF |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BW31 |