Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2390612..2391141 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag LVJ76_RS11205 Protein ID WP_003411124.1
Coordinates 2390612..2390929 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag LVJ76_RS11210 Protein ID WP_003411127.1
Coordinates 2390926..2391141 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS11175 (LVJ76_11195) 2385807..2386883 + 1077 WP_003411110.1 hypothetical protein -
LVJ76_RS11180 (LVJ76_11200) 2386880..2387161 + 282 WP_003411112.1 DUF5703 family protein -
LVJ76_RS11185 (LVJ76_11205) 2387197..2388270 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
LVJ76_RS11190 (LVJ76_11210) 2388275..2388805 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
LVJ76_RS11195 (LVJ76_11215) 2388853..2390199 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
LVJ76_RS11205 (LVJ76_11225) 2390612..2390929 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ76_RS11210 (LVJ76_11230) 2390926..2391141 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
LVJ76_RS11215 (LVJ76_11235) 2391396..2392454 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
LVJ76_RS11220 (LVJ76_11240) 2392584..2392940 - 357 WP_003411130.1 hypothetical protein -
LVJ76_RS11225 (LVJ76_11245) 2393035..2393817 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
LVJ76_RS11230 (LVJ76_11250) 2394085..2394375 - 291 WP_003900476.1 YggT family protein -
LVJ76_RS11235 (LVJ76_11255) 2394537..2395193 - 657 WP_003411133.1 cell division protein SepF -
LVJ76_RS11240 (LVJ76_11260) 2395259..2396035 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T229245 WP_003411124.1 NZ_CP089781:c2390929-2390612 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T229245 NZ_CP124424:779013-779387 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT229245 WP_003411127.1 NZ_CP089781:c2391141-2390926 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT229245 NZ_CP124424:778556-778924 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References