Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2242726..2243352 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag LVJ76_RS10510 Protein ID WP_003410075.1
Coordinates 2242954..2243352 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag LVJ76_RS10505 Protein ID WP_003911750.1
Coordinates 2242726..2242953 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS10495 (LVJ76_10510) 2240765..2241109 - 345 WP_003410065.1 ferredoxin family protein -
LVJ76_RS10500 (LVJ76_10515) 2241298..2242467 - 1170 WP_003899126.1 ATP-binding protein -
LVJ76_RS10505 (LVJ76_10520) 2242726..2242953 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ76_RS10510 (LVJ76_10525) 2242954..2243352 + 399 WP_003410075.1 PIN domain nuclease Toxin
LVJ76_RS10515 (LVJ76_10530) 2243535..2243966 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
LVJ76_RS10520 (LVJ76_10535) 2244067..2244501 + 435 WP_003914358.1 DUF1398 domain-containing protein -
LVJ76_RS10525 (LVJ76_10540) 2244938..2245117 - 180 Protein_2080 hypothetical protein -
LVJ76_RS10530 (LVJ76_10545) 2245205..2245825 + 621 WP_003410086.1 IS110 family transposase -
LVJ76_RS10535 (LVJ76_10550) 2245779..2246369 + 591 WP_003899131.1 IS110 family transposase -
LVJ76_RS10540 (LVJ76_10555) 2246497..2247753 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T229241 WP_003410075.1 NZ_CP089781:2242954-2243352 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

>T229241 NZ_CP124421:c108162-107857 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTTTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT229241 WP_003911750.1 NZ_CP089781:2242726-2242953 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp

>AT229241 NZ_CP124421:c108382-108164 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References