Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2217420..2218318 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag LVJ76_RS10385 Protein ID WP_003410001.1
Coordinates 2217420..2217980 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag LVJ76_RS10390 Protein ID WP_003410003.1
Coordinates 2217977..2218318 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS10355 (LVJ76_10370) 2212589..2213242 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ76_RS10360 (LVJ76_10375) 2213357..2213587 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ76_RS10365 (LVJ76_10380) 2213672..2214583 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ76_RS10370 (LVJ76_10385) 2214692..2215291 + 600 WP_003409989.1 L-lysine exporter -
LVJ76_RS10375 (LVJ76_10390) 2215707..2216135 + 429 WP_003906713.1 cellulose-binding protein -
LVJ76_RS10380 (LVJ76_10395) 2216361..2216900 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
LVJ76_RS10385 (LVJ76_10400) 2217420..2217980 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
LVJ76_RS10390 (LVJ76_10405) 2217977..2218318 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
LVJ76_RS10395 (LVJ76_10410) 2218404..2218661 + 258 WP_003410006.1 hypothetical protein -
LVJ76_RS10400 (LVJ76_10415) 2218562..2218897 - 336 WP_003410009.1 dehydrogenase -
LVJ76_RS10405 (LVJ76_10420) 2218986..2219330 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
LVJ76_RS10410 (LVJ76_10425) 2219324..2219572 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
LVJ76_RS10415 (LVJ76_10430) 2219672..2221987 - 2316 WP_003899120.1 cation transporter ATPase CptG -
LVJ76_RS10420 (LVJ76_10435) 2221984..2222256 - 273 WP_003410017.1 DUF1490 family protein -
LVJ76_RS10425 (LVJ76_10440) 2222309..2222665 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T229239 WP_003410001.1 NZ_CP089781:c2217980-2217420 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T229239 NZ_CP124420:4592331-4592633 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT229239 WP_003410003.1 NZ_CP089781:c2218318-2217977 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT229239 NZ_CP124420:4592669-4593010 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References