Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2188361..2188905 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag LVJ76_RS10220 Protein ID WP_003409896.1
Coordinates 2188361..2188657 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag LVJ76_RS10225 Protein ID WP_003409899.1
Coordinates 2188654..2188905 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS10165 (LVJ76_10180) 2183394..2183744 - 351 WP_003899096.1 hypothetical protein -
LVJ76_RS10170 (LVJ76_10185) 2183755..2184657 - 903 WP_003899097.1 hypothetical protein -
LVJ76_RS10175 (LVJ76_10190) 2184678..2184869 - 192 WP_003409876.1 hypothetical protein -
LVJ76_RS10180 (LVJ76_10195) 2184870..2185166 - 297 WP_003409877.1 hypothetical protein -
LVJ76_RS10185 (LVJ76_10200) 2185406..2185621 + 216 WP_003409878.1 antitoxin -
LVJ76_RS10190 (LVJ76_10205) 2185618..2185929 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
LVJ76_RS10195 (LVJ76_10210) 2185903..2186424 - 522 WP_003904745.1 hypothetical protein -
LVJ76_RS10200 (LVJ76_10215) 2186399..2186776 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
LVJ76_RS10205 (LVJ76_10220) 2186818..2187267 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA -
LVJ76_RS10210 (LVJ76_10225) 2187264..2187809 + 546 WP_003409891.1 SecB-like chaperone -
LVJ76_RS10215 (LVJ76_10230) 2187698..2188312 - 615 WP_003901296.1 hypothetical protein -
LVJ76_RS10220 (LVJ76_10235) 2188361..2188657 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LVJ76_RS10225 (LVJ76_10240) 2188654..2188905 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LVJ76_RS10230 (LVJ76_10245) 2188892..2189386 + 495 WP_003899099.1 hypothetical protein -
LVJ76_RS10235 (LVJ76_10250) 2189546..2189953 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
LVJ76_RS10240 (LVJ76_10255) 2189957..2190229 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ76_RS10245 (LVJ76_10260) 2190262..2191482 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -
LVJ76_RS10250 (LVJ76_10265) 2192381..2193178 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T229237 WP_003409896.1 NZ_CP089781:c2188657-2188361 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T229237 NZ_CP124420:4379063-4379983 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT229237 WP_003409899.1 NZ_CP089781:c2188905-2188654 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT229237 NZ_CP124420:4378294-4379076 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References