Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1933618..1934231 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ76_RS09025 Protein ID WP_003408465.1
Coordinates 1933618..1934007 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ76_RS09030 Protein ID WP_003408469.1
Coordinates 1934004..1934231 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS08990 (LVJ76_09000) 1929248..1930162 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ76_RS08995 (LVJ76_09005) 1930165..1930995 + 831 WP_003906661.1 cyclase family protein -
LVJ76_RS09000 (LVJ76_09010) 1930995..1931344 + 350 Protein_1776 cupin domain-containing protein -
LVJ76_RS09005 (LVJ76_09015) 1931397..1932215 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LVJ76_RS09010 (LVJ76_09020) 1932229..1933008 + 780 WP_003408460.1 IclR family transcriptional regulator -
LVJ76_RS09020 (LVJ76_09030) 1933439..1933570 + 132 Protein_1779 IS3 family transposase -
LVJ76_RS09025 (LVJ76_09035) 1933618..1934007 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ76_RS09030 (LVJ76_09040) 1934004..1934231 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ76_RS09035 (LVJ76_09045) 1934449..1935933 + 1485 WP_009937637.1 biotin carboxylase -
LVJ76_RS09040 (LVJ76_09050) 1935930..1937177 + 1248 WP_003408476.1 serine hydrolase -
LVJ76_RS09045 (LVJ76_09055) 1937220..1937639 - 420 WP_003408483.1 hypothetical protein -
LVJ76_RS09050 (LVJ76_09060) 1937629..1938339 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T229233 WP_003408465.1 NZ_CP089781:c1934007-1933618 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T229233 NZ_CP124420:3820391-3820741 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT229233 WP_003408469.1 NZ_CP089781:c1934231-1934004 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT229233 NZ_CP124420:3820146-3820397 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References