229230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1569813..1570468 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag LVJ76_RS07430 Protein ID WP_003898861.1
Coordinates 1569813..1570214 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag LVJ76_RS07435 Protein ID WP_003407272.1
Coordinates 1570211..1570468 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS07415 (LVJ76_07420) 1565286..1566671 - 1386 WP_003407260.1 cytochrome P450 -
LVJ76_RS07420 (LVJ76_07425) 1566749..1567783 + 1035 WP_003407264.1 AraC family transcriptional regulator -
LVJ76_RS07425 (LVJ76_07430) 1567829..1569558 - 1730 Protein_1462 PE family protein -
LVJ76_RS07430 (LVJ76_07435) 1569813..1570214 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ76_RS07435 (LVJ76_07440) 1570211..1570468 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
LVJ76_RS07440 (LVJ76_07445) 1570551..1571510 - 960 WP_003407276.1 alpha/beta hydrolase -
LVJ76_RS07445 (LVJ76_07450) 1571535..1572497 - 963 WP_003407279.1 alpha/beta hydrolase -
LVJ76_RS07450 (LVJ76_07455) 1572496..1573233 + 738 WP_031647000.1 lysoplasmalogenase -
LVJ76_RS07455 (LVJ76_07460) 1573314..1575281 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T229230 WP_003898861.1 NZ_CP089781:c1570214-1569813 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T229230 NZ_CP124420:c2991126-2991019 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT229230 WP_003407272.1 NZ_CP089781:c1570468-1570211 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT229230 NZ_CP124420:2991175-2991240 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References