Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1535450..1536500 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag LVJ76_RS07280 Protein ID WP_003407164.1
Coordinates 1535450..1536271 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag LVJ76_RS07285 Protein ID WP_003407167.1
Coordinates 1536264..1536500 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS07260 (LVJ76_07265) 1531008..1531670 - 663 WP_003407152.1 membrane protein -
LVJ76_RS07265 (LVJ76_07270) 1531667..1532452 - 786 WP_003407157.1 membrane protein -
LVJ76_RS07270 (LVJ76_07275) 1532743..1534704 - 1962 WP_003407159.1 sigma-F factor regulator -
LVJ76_RS07275 (LVJ76_07280) 1534843..1535229 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
LVJ76_RS07280 (LVJ76_07285) 1535450..1536271 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
LVJ76_RS07285 (LVJ76_07290) 1536264..1536500 + 237 WP_003407167.1 hypothetical protein Antitoxin
LVJ76_RS07290 (LVJ76_07295) 1536572..1537777 - 1206 WP_003898846.1 serine hydrolase domain-containing protein -
LVJ76_RS07295 (LVJ76_07300) 1538080..1538865 + 786 WP_003407180.1 lipoprotein LprF -
LVJ76_RS07300 (LVJ76_07305) 1539061..1540530 + 1470 WP_003900326.1 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T229229 WP_003407164.1 NZ_CP089781:1535450-1536271 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T229229 NZ_CP124420:c2990643-2990536 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT229229 WP_003407167.1 NZ_CP089781:1536264-1536500 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT229229 NZ_CP124420:2990700-2990757 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References