Detailed information of TA system TA229227

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1381547..1382235
• Replicon: chromosome
• Accession: NZ_CP089781
• Organism: Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: LVJ76_RS06610
• Protein ID: WP_003406304.1
• Coordinates: 1381804..1382235 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: LVJ76_RS06605
• Protein ID: WP_003406302.1
• Coordinates: 1381547..1381807 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ76_RS06585 (LVJ76_06585)	1377124..1377948	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
LVJ76_RS06590 (LVJ76_06590)	1377953..1379134	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
LVJ76_RS06595 (LVJ76_06595)	1379211..1380311	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
LVJ76_RS06600 (LVJ76_06600)	1380482..1381471	+	990	WP_003406301.1	malate dehydrogenase	-
LVJ76_RS06605 (LVJ76_06605)	1381547..1381807	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
LVJ76_RS06610 (LVJ76_06610)	1381804..1382235	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
LVJ76_RS06615 (LVJ76_06615)	1382258..1383946	-	1689	WP_003910308.1	PE family protein	-
LVJ76_RS06620 (LVJ76_06620)	1384126..1384986	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
LVJ76_RS06625 (LVJ76_06625)	1385067..1385897	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
LVJ76_RS06630 (LVJ76_06630)	1385954..1386247	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
LVJ76_RS06635 (LVJ76_06635)	1386244..1386513	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T229227 WP_003406304.1 NZ_CP089781:1381804-1382235 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T229227 NZ_CP124420:2575449-2575913 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT229227 WP_003406302.1 NZ_CP089781:1381547-1381807 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT229227 NZ_CP124420:2575114-2575449 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6