Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 712683..713332 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag LVJ76_RS03270 Protein ID WP_003403236.1
Coordinates 712937..713332 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag LVJ76_RS03265 Protein ID WP_003403235.1
Coordinates 712683..712937 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS03240 (LVJ76_03245) 707809..707892 + 84 Protein_642 galactose-1-phosphate uridylyltransferase -
LVJ76_RS03245 (LVJ76_03250) 707911..708992 + 1082 Protein_643 galactose-1-phosphate uridylyltransferase -
LVJ76_RS03250 (LVJ76_03255) 708989..710080 + 1092 WP_003906403.1 galactokinase -
LVJ76_RS03255 (LVJ76_03260) 710475..711539 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ76_RS03260 (LVJ76_03265) 711643..712590 + 948 WP_003403232.1 DUF732 domain-containing protein -
LVJ76_RS03265 (LVJ76_03270) 712683..712937 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
LVJ76_RS03270 (LVJ76_03275) 712937..713332 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
LVJ76_RS03275 (LVJ76_03280) 713426..714166 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
LVJ76_RS03280 (LVJ76_03285) 714298..714558 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LVJ76_RS03285 (LVJ76_03290) 714555..714962 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
LVJ76_RS03290 (LVJ76_03295) 715034..716185 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
LVJ76_RS03295 (LVJ76_03300) 716278..718005 - 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T229215 WP_003403236.1 NZ_CP089781:712937-713332 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T229215 NZ_CP124416:c115246-114941 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT229215 WP_003403235.1 NZ_CP089781:712683-712937 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT229215 NZ_CP124416:c115466-115248 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References