Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 707055..707680 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag LVJ76_RS03235 Protein ID WP_003403218.1
Coordinates 707279..707680 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag LVJ76_RS03230 Protein ID WP_003403213.1
Coordinates 707055..707282 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS03205 (LVJ76_03210) 702234..702455 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ76_RS03210 (LVJ76_03215) 702597..703202 + 606 WP_003898526.1 hypothetical protein -
LVJ76_RS03215 (LVJ76_03220) 703221..705788 - 2568 WP_009937370.1 SEC-C metal-binding domain-containing protein -
LVJ76_RS03220 (LVJ76_03225) 705872..706621 + 750 WP_003898528.1 hypothetical protein -
LVJ76_RS03225 (LVJ76_03230) 706618..706860 + 243 WP_003403210.1 hypothetical protein -
LVJ76_RS03230 (LVJ76_03235) 707055..707282 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
LVJ76_RS03235 (LVJ76_03240) 707279..707680 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
LVJ76_RS03240 (LVJ76_03245) 707809..707892 + 84 Protein_642 galactose-1-phosphate uridylyltransferase -
LVJ76_RS03245 (LVJ76_03250) 707911..708992 + 1082 Protein_643 galactose-1-phosphate uridylyltransferase -
LVJ76_RS03250 (LVJ76_03255) 708989..710080 + 1092 WP_003906403.1 galactokinase -
LVJ76_RS03255 (LVJ76_03260) 710475..711539 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
LVJ76_RS03260 (LVJ76_03265) 711643..712590 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T229214 WP_003403218.1 NZ_CP089781:707279-707680 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T229214 NZ_CP124416:c66548-66414 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT229214 WP_003403213.1 NZ_CP089781:707055-707282 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT229214 NZ_CP124416:66593-66653 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References