Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 699517..700160 Replicon chromosome
Accession NZ_CP089781
Organism Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag LVJ76_RS03185 Protein ID WP_003403187.1
Coordinates 699759..700160 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag LVJ76_RS03180 Protein ID WP_003403184.1
Coordinates 699517..699762 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ76_RS03145 (LVJ76_03150) 694797..695327 - 531 WP_003917320.1 two component system sensor kinase HK2 -
LVJ76_RS03150 (LVJ76_03155) 695311..696006 - 696 WP_003918099.1 two-component system response regulator TcrA -
LVJ76_RS03155 (LVJ76_03160) 696129..696440 + 312 WP_003403164.1 hypothetical protein -
LVJ76_RS03160 (LVJ76_03165) 696512..697462 + 951 WP_003900184.1 DUF1259 domain-containing protein -
LVJ76_RS03165 (LVJ76_03170) 697703..698287 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
LVJ76_RS03170 (LVJ76_03175) 698289..698999 + 711 Protein_628 IS607 family element RNA-guided endonuclease TnpB -
LVJ76_RS03175 (LVJ76_03180) 699002..699472 + 471 WP_003898523.1 hypothetical protein -
LVJ76_RS03180 (LVJ76_03185) 699517..699762 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ76_RS03185 (LVJ76_03190) 699759..700160 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ76_RS03190 (LVJ76_03195) 700151..700330 + 180 Protein_632 hypothetical protein -
LVJ76_RS03195 (LVJ76_03200) 700748..700945 - 198 WP_003403191.1 hypothetical protein -
LVJ76_RS03200 (LVJ76_03205) 701025..702182 - 1158 WP_003898524.1 hypothetical protein -
LVJ76_RS03205 (LVJ76_03210) 702234..702455 - 222 WP_003898525.1 DUF4926 domain-containing protein -
LVJ76_RS03210 (LVJ76_03215) 702597..703202 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T229213 WP_003403187.1 NZ_CP089781:699759-700160 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T229213 NZ_CP124415:c4892995-4892888 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT229213 WP_003403184.1 NZ_CP089781:699517-699762 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT229213 NZ_CP124415:4893043-4893109 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References