Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3103523..3105094 Replicon chromosome
Accession NC_010814
Organism Geobacter lovleyi SZ

Toxin (Protein)


Gene name hipA Uniprot ID B3E831
Locus tag GLOV_RS14315 Protein ID WP_012470929.1
Coordinates 3103523..3104842 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GLOV_RS14320 Protein ID WP_012470930.1
Coordinates 3104843..3105094 (-) Length 84 a.a.

Genomic Context

GLOV_RS19735GLOV_RS14310GLOV_RS19895GLOV_RS19985GLOV_RS14335GLOV_RS14340GLOV_RS14295GLOV_RS19890GLOV_RS14315GLOV_RS14320GLOV_RS14330
Location: 3101702..3101839 (138 bp)
Type: Others
Protein ID: Protein_2858
Location: 3102666..3102941 (276 bp)
Type: Others
Protein ID: Protein_2860
Location: 3102961..3103137 (177 bp)
Type: Others
Protein ID: WP_012470928.1
Location: 3105255..3105614 (360 bp)
Type: Others
Protein ID: WP_041242953.1
Location: 3106778..3108607 (1830 bp)
Type: Others
Protein ID: WP_012470932.1
Location: 3108604..3109488 (885 bp)
Type: Others
Protein ID: WP_049759709.1
Location: 3099863..3100294 (432 bp)
Type: Others
Protein ID: WP_012470924.1
Location: 3102198..3102491 (294 bp)
Type: Others
Protein ID: WP_167320576.1
Location: 3103523..3104842 (1320 bp)
Type: Toxin
Protein ID: WP_012470929.1
Location: 3104843..3105094 (252 bp)
Type: Antitoxin
Protein ID: WP_012470930.1
Location: 3105708..3106535 (828 bp)
Type: Others
Protein ID: WP_167320577.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GLOV_RS142953099863..3100294-432WP_012470924.1MarR family transcriptional regulator-
GLOV_RS197353101702..3101839+138Protein_2858NAD(P)/FAD-dependent oxidoreductase-
GLOV_RS198903102198..3102491-294WP_167320576.1ATP-binding protein-
GLOV_RS143103102666..3102941+276Protein_2860hypothetical protein-
GLOV_RS198953102961..3103137+177WP_012470928.1hypothetical protein-
GLOV_RS143153103523..3104842-1320WP_012470929.1type II toxin-antitoxin system HipA family toxinToxin
GLOV_RS143203104843..3105094-252WP_012470930.1helix-turn-helix domain-containing proteinAntitoxin
GLOV_RS199853105255..3105614+360WP_041242953.1DUF4573 domain-containing protein-
GLOV_RS143303105708..3106535-828WP_167320577.1radical SAM protein-
GLOV_RS143353106778..3108607+1830WP_012470932.1TonB-dependent receptor-
GLOV_RS143403108604..3109488+885WP_049759709.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(11-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-67)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49461.11 Da        Isoelectric Point: 7.4851

>T22921 WP_012470929.1 NC_010814:c3104842-3103523 [Geobacter lovleyi SZ]
MARPKITADLHLFMNGKKVGCLTRTAVGQLRFEYGDEWLHSAFRRPLSLSMPLSQKIFSGDVVENFFDNLLPDSQSIRSR
IQARFGAKSNRCFDLLWHVGRDCVGALQLLPEDAAEVDVRRIESEVLTDSQIAGLLRNYATLPLGMQGDNDFRISIAGAQ
EKTALLRLNDKWHRPLGVTPTSHIFKLPIGKIAHSGMDLTDSVENEWLCHLILKAYGIPVANADIATFEDVKVLVVERFD
RRWADDRSWLIRLPQEDMCQALNISPALKYESDGGPGIQRIMALLLGSVNALADRSLFLKTQVLFWLLGAIDGHAKNFSI
FLLPEGSFQLAPFYDVMSAYPLVEKRLVEPQKMKMAMAVRGKSTHYQWQKIQLRHWLSTAKACGFPADEMESIVKNLFGQ
MDDVIEHVQSILPQGFPEEVANSVFNGMKSVRSRFNTSL

Download         Length: 1320 bp

>T22921 NC_010814:c3104842-3103523 [Geobacter lovleyi SZ]
ATGGCCCGACCAAAAATAACAGCTGACCTGCACCTCTTTATGAACGGCAAAAAAGTAGGATGTCTGACTCGGACCGCAGT
TGGACAGCTTCGTTTTGAGTACGGTGACGAATGGCTGCATTCTGCATTCAGGCGACCGTTATCACTCTCGATGCCGCTCA
GTCAAAAGATTTTCAGCGGTGATGTGGTAGAAAACTTTTTTGACAACCTGCTGCCGGACAGCCAATCAATACGCAGCAGA
ATTCAGGCTCGATTCGGAGCAAAGAGTAATCGCTGTTTTGATCTTCTCTGGCACGTTGGACGGGATTGCGTCGGAGCGCT
CCAGCTTCTTCCAGAAGATGCTGCTGAAGTTGATGTGCGCCGGATTGAATCCGAGGTGCTTACAGATTCACAGATCGCGG
GGTTGTTGCGCAACTACGCAACCCTGCCACTCGGCATGCAGGGAGATAATGATTTTCGCATCTCGATAGCCGGAGCACAG
GAGAAGACTGCGCTGCTGCGCTTGAATGACAAGTGGCATCGCCCCCTGGGTGTCACACCGACCAGCCACATATTCAAACT
TCCAATCGGCAAGATTGCTCATAGTGGCATGGATCTGACCGACAGCGTGGAGAACGAATGGCTTTGTCATCTTATTCTCA
AGGCATACGGTATCCCAGTCGCCAATGCTGATATAGCAACGTTCGAGGATGTAAAGGTTCTGGTAGTGGAACGATTTGAT
CGCAGGTGGGCCGACGACCGTTCCTGGTTGATCCGTTTGCCGCAAGAAGATATGTGTCAGGCGCTGAACATATCACCGGC
CTTGAAATACGAAAGCGATGGCGGACCGGGCATTCAGCGCATCATGGCCCTGCTTCTGGGGTCGGTGAACGCGCTGGCGG
ATCGCAGCCTGTTTCTCAAGACCCAGGTGCTGTTCTGGCTACTTGGCGCCATCGATGGTCATGCAAAGAACTTCAGCATC
TTCCTGCTGCCGGAGGGTAGTTTTCAACTTGCCCCATTCTATGATGTCATGTCTGCCTATCCGCTCGTGGAGAAAAGGTT
GGTGGAACCACAAAAAATGAAAATGGCAATGGCTGTCAGAGGGAAAAGTACCCATTACCAGTGGCAAAAAATACAACTCC
GGCATTGGCTGTCTACTGCAAAAGCCTGCGGTTTTCCTGCGGATGAGATGGAGTCAATTGTTAAGAATTTGTTTGGCCAG
ATGGATGATGTTATTGAGCATGTGCAAAGCATTTTGCCACAGGGTTTTCCGGAAGAAGTTGCCAACTCCGTATTCAATGG
AATGAAAAGCGTACGAAGCCGCTTTAATACAAGCCTCTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9267.61 Da        Isoelectric Point: 10.0171

>AT22921 WP_012470930.1 NC_010814:c3105094-3104843 [Geobacter lovleyi SZ]
MVHKISSPETLGQALRAERKNKGMSQKVVGHSVGMEQHTISKIEKGNPGTELNTLFRLLAALDLELTIQPRQKPTFENTG
DQW

Download         Length: 252 bp

>AT22921 NC_010814:c3105094-3104843 [Geobacter lovleyi SZ]
ATGGTTCATAAAATCAGCTCACCAGAAACCCTTGGCCAAGCGTTGCGAGCTGAACGCAAAAACAAGGGAATGTCGCAGAA
AGTCGTCGGCCATTCTGTAGGCATGGAGCAACACACGATTTCTAAAATCGAAAAAGGAAACCCTGGCACTGAACTAAACA
CACTTTTTCGACTGCTCGCCGCTTTAGACCTTGAATTAACTATTCAACCTCGTCAGAAGCCTACCTTTGAAAATACGGGA
GACCAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB3E831

Antitoxin

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Source
ID
Structure
No matching records found

References