Detailed information of TA system TA022921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3103523..3105094
• Replicon: chromosome
• Accession: NC_010814
• Organism: Geobacter lovleyi SZ

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B3E831
• Locus tag: GLOV_RS14315
• Protein ID: WP_012470929.1
• Coordinates: 3103523..3104842 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GLOV_RS14320
• Protein ID: WP_012470930.1
• Coordinates: 3104843..3105094 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLOV_RS14295	3099863..3100294	-	432	WP_012470924.1	MarR family transcriptional regulator	-
GLOV_RS19735	3101702..3101839	+	138	Protein_2858	NAD(P)/FAD-dependent oxidoreductase	-
GLOV_RS19890	3102198..3102491	-	294	WP_167320576.1	ATP-binding protein	-
GLOV_RS14310	3102666..3102941	+	276	Protein_2860	hypothetical protein	-
GLOV_RS19895	3102961..3103137	+	177	WP_012470928.1	hypothetical protein	-
GLOV_RS14315	3103523..3104842	-	1320	WP_012470929.1	type II toxin-antitoxin system HipA family toxin	Toxin
GLOV_RS14320	3104843..3105094	-	252	WP_012470930.1	helix-turn-helix domain-containing protein	Antitoxin
GLOV_RS19985	3105255..3105614	+	360	WP_041242953.1	DUF4573 domain-containing protein	-
GLOV_RS14330	3105708..3106535	-	828	WP_167320577.1	radical SAM protein	-
GLOV_RS14335	3106778..3108607	+	1830	WP_012470932.1	TonB-dependent receptor	-
GLOV_RS14340	3108604..3109488	+	885	WP_049759709.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (11-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-67)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49461.11 Da
• Isoelectric Point: 7.4851

>T22921 WP_012470929.1 NC_010814:c3104842-3103523 [Geobacter lovleyi SZ]
MARPKITADLHLFMNGKKVGCLTRTAVGQLRFEYGDEWLHSAFRRPLSLSMPLSQKIFSGDVVENFFDNLLPDSQSIRSR
IQARFGAKSNRCFDLLWHVGRDCVGALQLLPEDAAEVDVRRIESEVLTDSQIAGLLRNYATLPLGMQGDNDFRISIAGAQ
EKTALLRLNDKWHRPLGVTPTSHIFKLPIGKIAHSGMDLTDSVENEWLCHLILKAYGIPVANADIATFEDVKVLVVERFD
RRWADDRSWLIRLPQEDMCQALNISPALKYESDGGPGIQRIMALLLGSVNALADRSLFLKTQVLFWLLGAIDGHAKNFSI
FLLPEGSFQLAPFYDVMSAYPLVEKRLVEPQKMKMAMAVRGKSTHYQWQKIQLRHWLSTAKACGFPADEMESIVKNLFGQ
MDDVIEHVQSILPQGFPEEVANSVFNGMKSVRSRFNTSL

Nucleotide

• Length: 1320 bp

>T22921 NC_010814:c3104842-3103523 [Geobacter lovleyi SZ]
ATGGCCCGACCAAAAATAACAGCTGACCTGCACCTCTTTATGAACGGCAAAAAAGTAGGATGTCTGACTCGGACCGCAGT
TGGACAGCTTCGTTTTGAGTACGGTGACGAATGGCTGCATTCTGCATTCAGGCGACCGTTATCACTCTCGATGCCGCTCA
GTCAAAAGATTTTCAGCGGTGATGTGGTAGAAAACTTTTTTGACAACCTGCTGCCGGACAGCCAATCAATACGCAGCAGA
ATTCAGGCTCGATTCGGAGCAAAGAGTAATCGCTGTTTTGATCTTCTCTGGCACGTTGGACGGGATTGCGTCGGAGCGCT
CCAGCTTCTTCCAGAAGATGCTGCTGAAGTTGATGTGCGCCGGATTGAATCCGAGGTGCTTACAGATTCACAGATCGCGG
GGTTGTTGCGCAACTACGCAACCCTGCCACTCGGCATGCAGGGAGATAATGATTTTCGCATCTCGATAGCCGGAGCACAG
GAGAAGACTGCGCTGCTGCGCTTGAATGACAAGTGGCATCGCCCCCTGGGTGTCACACCGACCAGCCACATATTCAAACT
TCCAATCGGCAAGATTGCTCATAGTGGCATGGATCTGACCGACAGCGTGGAGAACGAATGGCTTTGTCATCTTATTCTCA
AGGCATACGGTATCCCAGTCGCCAATGCTGATATAGCAACGTTCGAGGATGTAAAGGTTCTGGTAGTGGAACGATTTGAT
CGCAGGTGGGCCGACGACCGTTCCTGGTTGATCCGTTTGCCGCAAGAAGATATGTGTCAGGCGCTGAACATATCACCGGC
CTTGAAATACGAAAGCGATGGCGGACCGGGCATTCAGCGCATCATGGCCCTGCTTCTGGGGTCGGTGAACGCGCTGGCGG
ATCGCAGCCTGTTTCTCAAGACCCAGGTGCTGTTCTGGCTACTTGGCGCCATCGATGGTCATGCAAAGAACTTCAGCATC
TTCCTGCTGCCGGAGGGTAGTTTTCAACTTGCCCCATTCTATGATGTCATGTCTGCCTATCCGCTCGTGGAGAAAAGGTT
GGTGGAACCACAAAAAATGAAAATGGCAATGGCTGTCAGAGGGAAAAGTACCCATTACCAGTGGCAAAAAATACAACTCC
GGCATTGGCTGTCTACTGCAAAAGCCTGCGGTTTTCCTGCGGATGAGATGGAGTCAATTGTTAAGAATTTGTTTGGCCAG
ATGGATGATGTTATTGAGCATGTGCAAAGCATTTTGCCACAGGGTTTTCCGGAAGAAGTTGCCAACTCCGTATTCAATGG
AATGAAAAGCGTACGAAGCCGCTTTAATACAAGCCTCTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9267.61 Da
• Isoelectric Point: 10.0171

>AT22921 WP_012470930.1 NC_010814:c3105094-3104843 [Geobacter lovleyi SZ]
MVHKISSPETLGQALRAERKNKGMSQKVVGHSVGMEQHTISKIEKGNPGTELNTLFRLLAALDLELTIQPRQKPTFENTG
DQW

Nucleotide

• Length: 252 bp

>AT22921 NC_010814:c3105094-3104843 [Geobacter lovleyi SZ]
ATGGTTCATAAAATCAGCTCACCAGAAACCCTTGGCCAAGCGTTGCGAGCTGAACGCAAAAACAAGGGAATGTCGCAGAA
AGTCGTCGGCCATTCTGTAGGCATGGAGCAACACACGATTTCTAAAATCGAAAAAGGAAACCCTGGCACTGAACTAAACA
CACTTTTTCGACTGCTCGCCGCTTTAGACCTTGAATTAACTATTCAACCTCGTCAGAAGCCTACCTTTGAAAATACGGGA
GACCAGTGGTAA

Structures

Toxin

• AlphaFold DB: B3E831