Detailed information of TA system TA229205

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 362603..363129
• Replicon: chromosome
• Accession: NZ_CP089781
• Organism: Mycobacterium tuberculosis strain 02-R1179

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: LVJ76_RS01580
• Protein ID: WP_003401560.1
• Coordinates: 362827..363129 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: LVJ76_RS01575
• Protein ID: WP_003401555.1
• Coordinates: 362603..362830 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ76_RS01560 (LVJ76_01560)	358296..359099	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
LVJ76_RS01565 (LVJ76_01565)	359109..360506	-	1398	WP_003401544.1	sulfatase	-
LVJ76_RS01570 (LVJ76_01570)	360685..362460	+	1776	WP_010886074.1	PE family protein	-
LVJ76_RS01575 (LVJ76_01575)	362603..362830	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
LVJ76_RS01580 (LVJ76_01580)	362827..363129	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
LVJ76_RS01585 (LVJ76_01585)	363177..363398	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
LVJ76_RS01590 (LVJ76_01590)	363395..363820	+	426	WP_003401566.1	PIN domain nuclease	-
LVJ76_RS01595 (LVJ76_01595)	363956..364588	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
LVJ76_RS01600 (LVJ76_01600)	364585..365493	+	909	WP_003900117.1	protochlorophyllide reductase	-
LVJ76_RS01605 (LVJ76_01605)	365501..366091	-	591	WP_229298012.1	hypothetical protein	-
LVJ76_RS01610 (LVJ76_01610)	366084..366134	-	51	Protein_318	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T229205 WP_003401560.1 NZ_CP089781:362827-363129 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T229205 NZ_CP124415:3222835-3223008 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT229205 WP_003401555.1 NZ_CP089781:362603-362830 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT229205 NZ_CP124415:3222511-3222807 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1