229203

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3832102..3832787 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag LVJ75_RS18025 Protein ID WP_003417998.1
Coordinates 3832377..3832787 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LVJ75_RS18020 Protein ID WP_180895138.1
Coordinates 3832102..3832380 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS18000 (LVJ75_17985) 3828091..3829692 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
LVJ75_RS18005 (LVJ75_17990) 3829709..3830413 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
LVJ75_RS18010 (LVJ75_17995) 3830531..3831097 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
LVJ75_RS18015 (LVJ75_18000) 3831159..3832046 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
LVJ75_RS18020 (LVJ75_18005) 3832102..3832380 + 279 WP_180895138.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LVJ75_RS18025 (LVJ75_18010) 3832377..3832787 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ75_RS18030 (LVJ75_18015) 3832820..3834556 - 1737 WP_003418002.1 cholesterol oxidase -
LVJ75_RS18035 (LVJ75_18020) 3834612..3835739 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
LVJ75_RS18040 (LVJ75_18025) 3835759..3837348 - 1590 WP_003901630.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-58)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T229203 WP_003417998.1 NZ_CP089780:3832377-3832787 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T229203 NZ_CP124415:c2496812-2496705 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10227.70 Da        Isoelectric Point: 8.0222

>AT229203 WP_180895138.1 NZ_CP089780:3832102-3832380 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGCKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT229203 NZ_CP124415:2496861-2496926 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References