Detailed information of TA system TA022920

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2772435..2772979
• Replicon: chromosome
• Accession: NC_010814
• Organism: Geobacter lovleyi SZ

Toxin (Protein)

• Gene name: parE
• Uniprot ID: B3E6F1
• Locus tag: GLOV_RS12790
• Protein ID: WP_012470630.1
• Coordinates: 2772435..2772737 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B3E6F2
• Locus tag: GLOV_RS12795
• Protein ID: WP_012470631.1
• Coordinates: 2772737..2772979 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLOV_RS12770	2768235..2769137	+	903	WP_012470625.1	class A beta-lactamase	-
GLOV_RS12775	2769405..2770424	+	1020	WP_012470626.1	ParA family protein	-
GLOV_RS19330	2770600..2771235	+	636	WP_012470627.1	DUF4433 domain-containing protein	-
GLOV_RS12780	2771346..2772050	+	705	WP_012470628.1	hypothetical protein	-
GLOV_RS12785	2772138..2772416	+	279	WP_012470629.1	hypothetical protein	-
GLOV_RS12790	2772435..2772737	-	303	WP_012470630.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GLOV_RS12795	2772737..2772979	-	243	WP_012470631.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GLOV_RS12800	2773181..2773720	-	540	WP_012470632.1	thioredoxin fold domain-containing protein	-
GLOV_RS12805	2773946..2775025	-	1080	WP_012470633.1	LPS export ABC transporter permease LptG	-
GLOV_RS12810	2775025..2776164	-	1140	WP_012470634.1	LPS export ABC transporter permease LptF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11651.51 Da
• Isoelectric Point: 9.5980

>T22920 WP_012470630.1 NC_010814:c2772737-2772435 [Geobacter lovleyi SZ]
MPSFTLTNMAKADLKEIAKFTQNRWGREQRDLYLQMLDVSFRQLAVNPLKGKDCSDIRIGYRKLLAGSHVIFYRQTLTDT
IEIVRVLHGHMDIETRLSEP

Nucleotide

• Length: 303 bp

>T22920 NC_010814:c2772737-2772435 [Geobacter lovleyi SZ]
ATGCCTTCTTTTACCCTCACCAACATGGCTAAGGCTGATTTGAAAGAGATCGCCAAGTTCACCCAAAACCGCTGGGGGCG
TGAACAGCGTGATTTGTATCTACAAATGTTGGACGTTTCATTCCGTCAGTTGGCTGTCAATCCGCTTAAAGGGAAAGATT
GCAGCGATATTCGCATTGGCTACCGGAAATTGCTTGCTGGTAGCCATGTAATTTTTTACCGCCAAACGCTTACCGATACT
ATCGAGATTGTCCGTGTTTTGCACGGGCATATGGACATTGAAACACGACTTTCTGAACCGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8874.98 Da
• Isoelectric Point: 5.8255

>AT22920 WP_012470631.1 NC_010814:c2772979-2772737 [Geobacter lovleyi SZ]
MQKNTSVTLGKHYENFISQQVVQGRFGSASETIRAGLRLLEERETKLSLLRRSLIEGEESGIADYSLSGLLAELDGKSFN

Nucleotide

• Length: 243 bp

>AT22920 NC_010814:c2772979-2772737 [Geobacter lovleyi SZ]
ATGCAAAAAAACACCAGTGTTACTCTCGGCAAACACTACGAAAATTTCATTTCTCAGCAGGTTGTTCAAGGCCGTTTTGG
TTCAGCAAGTGAGACAATCCGAGCCGGTCTGCGACTGTTGGAAGAACGGGAGACCAAGTTGTCTTTGTTGCGCCGTTCGC
TAATTGAGGGAGAAGAAAGCGGCATCGCTGATTATTCGCTTTCGGGTTTACTGGCAGAACTTGACGGCAAAAGTTTCAAC
TGA

Structures

Toxin

• AlphaFold DB: B3E6F1

Antitoxin

• AlphaFold DB: B3E6F2