Detailed information of TA system TA229197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3167115..3167663
• Replicon: chromosome
• Accession: NZ_CP089780
• Organism: Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TFG5
• Locus tag: LVJ75_RS15105
• Protein ID: WP_003414602.1
• Coordinates: 3167400..3167663 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: O33347
• Locus tag: LVJ75_RS15100
• Protein ID: WP_003414599.1
• Coordinates: 3167115..3167396 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ75_RS15075 (LVJ75_15060)	3162739..3163596	-	858	WP_003899513.1	type I methionyl aminopeptidase	-
LVJ75_RS15080 (LVJ75_15065)	3163638..3164222	-	585	WP_003414585.1	DUF1707 domain-containing protein	-
LVJ75_RS15085 (LVJ75_15070)	3164325..3164573	+	249	WP_003913411.1	antitoxin VapB23	-
LVJ75_RS15090 (LVJ75_15075)	3164570..3164950	+	381	WP_003414592.1	type II toxin-antitoxin system VapC family toxin	-
LVJ75_RS15095 (LVJ75_15080)	3165032..3166843	-	1812	WP_003414596.1	penicillin-binding protein	-
LVJ75_RS15100 (LVJ75_15085)	3167115..3167396	+	282	WP_003414599.1	type II toxin-antitoxin system antitoxin RelF	Antitoxin
LVJ75_RS15105 (LVJ75_15090)	3167400..3167663	+	264	WP_003414602.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LVJ75_RS15110 (LVJ75_15095)	3168036..3168890	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
LVJ75_RS15115 (LVJ75_15100)	3168946..3170109	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
LVJ75_RS15120 (LVJ75_15105)	3170126..3171340	-	1215	WP_003414610.1	zinc metalloprotease Rip	-
LVJ75_RS15125 (LVJ75_15110)	3171348..3172589	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10204.82 Da
• Isoelectric Point: 11.5078

>T229197 WP_003414602.1 NZ_CP089780:3167400-3167663 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Nucleotide

• Length: 264 bp

>T229197 NZ_CP124415:c1715855-1715448 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10183.40 Da
• Isoelectric Point: 4.3440

>AT229197 WP_003414599.1 NZ_CP089780:3167115-3167396 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Nucleotide

• Length: 282 bp

>AT229197 NZ_CP124415:c1716102-1715836 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• PDB: 3G5O

Antitoxin

• AlphaFold DB: A0A7U4BWP8