Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 2641544..2642103 Replicon chromosome
Accession NC_010814
Organism Geobacter lovleyi SZ

Toxin (Protein)


Gene name mazF Uniprot ID B3E5U4
Locus tag GLOV_RS12240 Protein ID WP_012470518.1
Coordinates 2641858..2642103 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B3E5U3
Locus tag GLOV_RS12235 Protein ID WP_012470517.1
Coordinates 2641544..2641867 (-) Length 108 a.a.

Genomic Context

GLOV_RS12225GLOV_RS12230GLOV_RS12235GLOV_RS12240GLOV_RS12245GLOV_RS12250GLOV_RS12255GLOV_RS12260GLOV_RS12265
Location: 2636729..2637169 (441 bp)
Type: Others
Protein ID: WP_012470515.1
Location: 2637263..2638021 (759 bp)
Type: Others
Protein ID: WP_012470516.1
Location: 2641544..2641867 (324 bp)
Type: Antitoxin
Protein ID: WP_012470517.1
Location: 2641858..2642103 (246 bp)
Type: Toxin
Protein ID: WP_012470518.1
Location: 2642164..2642457 (294 bp)
Type: Others
Protein ID: WP_012470519.1
Location: 2642605..2642970 (366 bp)
Type: Others
Protein ID: WP_012470520.1
Location: 2643102..2644025 (924 bp)
Type: Others
Protein ID: WP_012470521.1
Location: 2644426..2645304 (879 bp)
Type: Others
Protein ID: WP_012470522.1
Location: 2645304..2646119 (816 bp)
Type: Others
Protein ID: WP_012470523.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GLOV_RS122252636729..2637169-441WP_012470515.1transcriptional repressor-
GLOV_RS122302637263..2638021-759WP_012470516.1hypothetical protein-
GLOV_RS122352641544..2641867-324WP_012470517.1type II toxin-antitoxin system PemK/MazF family toxinAntitoxin
GLOV_RS122402641858..2642103-246WP_012470518.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinToxin
GLOV_RS122452642164..2642457-294WP_012470519.1type I-E CRISPR-associated endoribonuclease Cas2-
GLOV_RS122502642605..2642970-366WP_012470520.1DUF559 domain-containing protein-
GLOV_RS122552643102..2644025-924WP_012470521.1type I-E CRISPR-associated endonuclease Cas1-
GLOV_RS122602644426..2645304-879WP_012470522.1type I-E CRISPR-associated protein Cas6/Cse3/CasE-
GLOV_RS122652645304..2646119-816WP_012470523.1type I-E CRISPR-associated protein Cas5/CasD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(8-48)

Antitoxin

mRNA interferase PemK-like

(4-105)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9023.26 Da        Isoelectric Point: 4.2676

>T22919 WP_012470518.1 NC_010814:c2642103-2641858 [Geobacter lovleyi SZ]
MLAQLVSIGNSKGIRIPAALLRQYGLSDTVELLPGKDEITIRPVKAKPREGWDQSFAAMHATGDDALLIDEMLDQEDWEW
S

Download         Length: 246 bp

>T22919 NC_010814:c2642103-2641858 [Geobacter lovleyi SZ]
ATGCTTGCACAATTGGTTTCCATAGGTAATTCAAAGGGCATACGGATACCTGCGGCGTTGCTGCGTCAATACGGTTTAAG
CGACACGGTTGAGCTGTTGCCGGGCAAAGATGAGATTACTATTCGTCCGGTAAAAGCTAAGCCCCGCGAAGGCTGGGATC
AGTCCTTTGCTGCCATGCATGCCACCGGAGATGATGCGCTGCTGATTGACGAAATGCTTGATCAGGAGGACTGGGAGTGG
AGCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12349.47 Da        Isoelectric Point: 10.1377

>AT22919 WP_012470517.1 NC_010814:c2641867-2641544 [Geobacter lovleyi SZ]
VELKQYHVYLVNLDPTIGHEIQKTRPCLIISPDEMNRHLQTVMIAPMTTKSHNYPSRVSLAFTGKQAWIVLDQIRTVDRR
RLVKELGKITTQQAQNVKAVLKEMLVD

Download         Length: 324 bp

>AT22919 NC_010814:c2641867-2641544 [Geobacter lovleyi SZ]
GTGGAGCTGAAACAATACCATGTGTATCTGGTGAATCTTGACCCAACCATTGGACATGAAATTCAAAAGACACGGCCCTG
TCTGATTATCTCTCCTGATGAGATGAACCGGCATCTGCAAACGGTTATGATTGCCCCCATGACCACCAAATCCCATAACT
ACCCAAGCCGTGTATCGCTTGCCTTTACCGGTAAACAAGCATGGATTGTGCTTGACCAGATTCGCACGGTGGACCGTAGG
CGGCTGGTGAAAGAACTGGGTAAGATAACCACCCAGCAGGCTCAGAACGTAAAAGCTGTGCTCAAAGAAATGTTGGTTGA
TTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB3E5U4

Antitoxin

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Source
ID
Structure
AlphaFold DBB3E5U3

References