22919

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(antitoxin)
Location 2641544..2642103 Replicon chromosome
Accession NC_010814
Organism Geobacter lovleyi SZ

Toxin (Protein)


Gene name mazF Uniprot ID B3E5U4
Locus tag GLOV_RS12240 Protein ID WP_012470518.1
Coordinates 2641858..2642103 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B3E5U3
Locus tag GLOV_RS12235 Protein ID WP_012470517.1
Coordinates 2641544..2641867 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLOV_RS12225 2636729..2637169 - 441 WP_012470515.1 transcriptional repressor -
GLOV_RS12230 2637263..2638021 - 759 WP_012470516.1 hypothetical protein -
GLOV_RS12235 2641544..2641867 - 324 WP_012470517.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
GLOV_RS12240 2641858..2642103 - 246 WP_012470518.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
GLOV_RS12245 2642164..2642457 - 294 WP_012470519.1 type I-E CRISPR-associated endoribonuclease Cas2 -
GLOV_RS12250 2642605..2642970 - 366 WP_012470520.1 DUF559 domain-containing protein -
GLOV_RS12255 2643102..2644025 - 924 WP_012470521.1 type I-E CRISPR-associated endonuclease Cas1 -
GLOV_RS12260 2644426..2645304 - 879 WP_012470522.1 type I-E CRISPR-associated protein Cas6/Cse3/CasE -
GLOV_RS12265 2645304..2646119 - 816 WP_012470523.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(8-48)

Antitoxin

mRNA interferase PemK-like

(4-105)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9023.26 Da        Isoelectric Point: 4.2676

>T22919 WP_012470518.1 NC_010814:c2642103-2641858 [Geobacter lovleyi SZ]
MLAQLVSIGNSKGIRIPAALLRQYGLSDTVELLPGKDEITIRPVKAKPREGWDQSFAAMHATGDDALLIDEMLDQEDWEW
S

Download         Length: 246 bp

>T22919 NC_010814:c2642103-2641858 [Geobacter lovleyi SZ]
ATGCTTGCACAATTGGTTTCCATAGGTAATTCAAAGGGCATACGGATACCTGCGGCGTTGCTGCGTCAATACGGTTTAAG
CGACACGGTTGAGCTGTTGCCGGGCAAAGATGAGATTACTATTCGTCCGGTAAAAGCTAAGCCCCGCGAAGGCTGGGATC
AGTCCTTTGCTGCCATGCATGCCACCGGAGATGATGCGCTGCTGATTGACGAAATGCTTGATCAGGAGGACTGGGAGTGG
AGCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12349.47 Da        Isoelectric Point: 10.1377

>AT22919 WP_012470517.1 NC_010814:c2641867-2641544 [Geobacter lovleyi SZ]
VELKQYHVYLVNLDPTIGHEIQKTRPCLIISPDEMNRHLQTVMIAPMTTKSHNYPSRVSLAFTGKQAWIVLDQIRTVDRR
RLVKELGKITTQQAQNVKAVLKEMLVD

Download         Length: 324 bp

>AT22919 NC_010814:c2641867-2641544 [Geobacter lovleyi SZ]
GTGGAGCTGAAACAATACCATGTGTATCTGGTGAATCTTGACCCAACCATTGGACATGAAATTCAAAAGACACGGCCCTG
TCTGATTATCTCTCCTGATGAGATGAACCGGCATCTGCAAACGGTTATGATTGCCCCCATGACCACCAAATCCCATAACT
ACCCAAGCCGTGTATCGCTTGCCTTTACCGGTAAACAAGCATGGATTGTGCTTGACCAGATTCGCACGGTGGACCGTAGG
CGGCTGGTGAAAGAACTGGGTAAGATAACCACCCAGCAGGCTCAGAACGTAAAAGCTGTGCTCAAAGAAATGTTGGTTGA
TTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B3E5U4

Antitoxin

Source ID Structure
AlphaFold DB B3E5U3

References