Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 2865097..2865806 | Replicon | chromosome |
| Accession | NZ_CP089780 | ||
| Organism | Mycobacterium tuberculosis strain M0003941-3 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ26 |
| Locus tag | LVJ75_RS13445 | Protein ID | WP_003413164.1 |
| Coordinates | 2865097..2865510 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | P95006 |
| Locus tag | LVJ75_RS13450 | Protein ID | WP_003413167.1 |
| Coordinates | 2865549..2865806 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ75_RS13415 (LVJ75_13400) | 2860151..2861356 | - | 1206 | WP_003413027.1 | chorismate synthase | - |
| LVJ75_RS13420 (LVJ75_13405) | 2861464..2861778 | + | 315 | WP_009937839.1 | hypothetical protein | - |
| LVJ75_RS13425 (LVJ75_13410) | 2862074..2863285 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
| LVJ75_RS13430 (LVJ75_13415) | 2863412..2864071 | + | 660 | WP_003902296.1 | LppA family lipoprotein | - |
| LVJ75_RS13435 (LVJ75_13420) | 2864068..2864730 | + | 663 | WP_003905878.1 | LppA family lipoprotein | - |
| LVJ75_RS13440 (LVJ75_13425) | 2864727..2865004 | + | 278 | Protein_2653 | type II toxin-antitoxin system VapB family antitoxin | - |
| LVJ75_RS13445 (LVJ75_13430) | 2865097..2865510 | + | 414 | WP_003413164.1 | PIN domain nuclease | Toxin |
| LVJ75_RS13450 (LVJ75_13435) | 2865549..2865806 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | Antitoxin |
| LVJ75_RS13455 (LVJ75_13440) | 2865803..2866180 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ75_RS13460 (LVJ75_13445) | 2866196..2866570 | - | 375 | WP_003413177.1 | hypothetical protein | - |
| LVJ75_RS13465 (LVJ75_13450) | 2866670..2867065 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
| LVJ75_RS13470 (LVJ75_13455) | 2867062..2867307 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
| LVJ75_RS13475 (LVJ75_13460) | 2867718..2868137 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
| LVJ75_RS13480 (LVJ75_13465) | 2868149..2868958 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
| LVJ75_RS13485 (LVJ75_13470) | 2868955..2870208 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
| LVJ75_RS13490 (LVJ75_13475) | 2870201..2870713 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15045.00 Da Isoelectric Point: 5.4673
>T229187 WP_003413164.1 NZ_CP089780:2865097-2865510 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL
Download Length: 414 bp
>T229187 NZ_CP124410:4103942-4104244 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT229187 WP_003413167.1 NZ_CP089780:2865549-2865806 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT229187 NZ_CP124410:4104280-4104621 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829C9W5 |