Detailed information of TA system TA229183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2364200..2364895
• Replicon: chromosome
• Accession: NZ_CP089780
• Organism: Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LVJ75_RS11050
• Protein ID: WP_003905754.1
• Coordinates: 2364200..2364634 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: LVJ75_RS11055
• Protein ID: WP_003410814.1
• Coordinates: 2364641..2364895 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ75_RS11040 (LVJ75_11035)	2360354..2363395	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
LVJ75_RS11045 (LVJ75_11040)	2363388..2364221	+	834	WP_003899172.1	SWIM zinc finger family protein	-
LVJ75_RS11050 (LVJ75_11045)	2364200..2364634	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
LVJ75_RS11055 (LVJ75_11050)	2364641..2364895	-	255	WP_003410814.1	antitoxin	Antitoxin
LVJ75_RS11060 (LVJ75_11055)	2364911..2365168	-	258	WP_003410816.1	hypothetical protein	-
LVJ75_RS11065 (LVJ75_11060)	2365702..2366963	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
LVJ75_RS11070 (LVJ75_11065)	2367473..2367769	+	297	WP_003410820.1	PE family protein	-
LVJ75_RS11075 (LVJ75_11070)	2367825..2368556	+	732	WP_003900467.1	PPE family protein	-
LVJ75_RS11080 (LVJ75_11075)	2369096..2369842	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T229183 WP_003905754.1 NZ_CP089780:c2364634-2364200 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T229183 NZ_CP124410:3512620-3512907 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT229183 WP_003410814.1 NZ_CP089780:c2364895-2364641 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT229183 NZ_CP124410:3512894-3513196 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: G0TMN0