Detailed information of TA system TA022918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2412302..2412885
• Replicon: chromosome
• Accession: NC_010814
• Organism: Geobacter lovleyi SZ

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GLOV_RS19300
• Protein ID: WP_012470311.1
• Coordinates: 2412631..2412885 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B3E4P0
• Locus tag: GLOV_RS11200
• Protein ID: WP_012470310.1
• Coordinates: 2412302..2412634 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLOV_RS11180	2408140..2408904	+	765	WP_041242803.1	IS21-like element helper ATPase IstB	-
GLOV_RS19670	2409330..2409497	-	168	WP_153304682.1	hypothetical protein	-
GLOV_RS11190	2409994..2411211	+	1218	WP_012470308.1	IS256 family transposase	-
GLOV_RS11195	2411572..2412063	+	492	WP_012470309.1	hypothetical protein	-
GLOV_RS11200	2412302..2412634	-	333	WP_012470310.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GLOV_RS19300	2412631..2412885	-	255	WP_012470311.1	type II toxin-antitoxin system HicA family toxin	Toxin
GLOV_RS11205	2413204..2414049	+	846	WP_012470312.1	response regulator	-
GLOV_RS19865	2414071..2414241	-	171	WP_012470313.1	hypothetical protein	-
GLOV_RS11210	2414247..2414546	-	300	WP_012470314.1	MTH1187 family thiamine-binding protein	-
GLOV_RS11215	2414649..2415530	+	882	WP_012470315.1	radical SAM protein	-
GLOV_RS11220	2415706..2417139	+	1434	WP_012470316.1	PfaD family polyunsaturated fatty acid/polyketide biosynthesis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-73)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9335.69 Da
• Isoelectric Point: 10.7636

>T22918 WP_012470311.1 NC_010814:c2412885-2412631 [Geobacter lovleyi SZ]
VNNKHRKTLDAIFIEPALSNIAWSDIESLLIAVGAQRFEGNGSRVRFLLNDVKATFHRPHPQKETDKGAVVSVRRFLEAG
GVKP

Nucleotide

• Length: 255 bp

>T22918 NC_010814:c2412885-2412631 [Geobacter lovleyi SZ]
GTGAATAACAAACACCGCAAGACGTTGGATGCAATATTCATTGAGCCAGCCCTTTCAAATATTGCATGGTCTGACATTGA
GTCTTTGCTTATAGCCGTCGGAGCGCAAAGATTTGAAGGCAACGGCTCACGAGTACGGTTTTTGTTGAATGACGTAAAGG
CGACCTTTCACCGACCACACCCGCAAAAGGAAACGGACAAAGGTGCAGTCGTTTCGGTAAGAAGATTTCTTGAGGCAGGA
GGTGTAAAGCCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12640.34 Da
• Isoelectric Point: 5.5455

>AT22918 WP_012470310.1 NC_010814:c2412634-2412302 [Geobacter lovleyi SZ]
MMEYKGYIGKVEFDDEAEIFHGEVVNTRDVITFQGTTVAEIKQAFHDSVEDYLDFCAQLGHEPEKPFTGKFMVRIPPDLH
RRIYSSARIAGKSMNAWVIEQLKQSTAFVH

Nucleotide

• Length: 333 bp

>AT22918 NC_010814:c2412634-2412302 [Geobacter lovleyi SZ]
ATGATGGAATATAAAGGATATATTGGCAAAGTCGAGTTTGATGATGAAGCAGAAATCTTTCACGGTGAAGTAGTTAACAC
CCGTGATGTAATAACATTTCAAGGAACCACAGTAGCCGAAATAAAGCAGGCTTTTCATGATTCTGTAGAAGACTATCTTG
ATTTCTGCGCCCAACTTGGCCATGAACCGGAAAAACCATTTACTGGCAAGTTCATGGTTCGTATCCCGCCTGACCTCCAC
CGTAGGATATATTCTTCCGCCCGTATTGCCGGGAAAAGCATGAATGCATGGGTAATTGAGCAACTAAAGCAATCCACCGC
ATTTGTACATTAA

Structures

Antitoxin

• AlphaFold DB: B3E4P0