229177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2217733..2218421 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag LVJ75_RS10375 Protein ID WP_003409958.1
Coordinates 2217733..2218152 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag LVJ75_RS10380 Protein ID WP_003409968.1
Coordinates 2218161..2218421 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS10355 (LVJ75_10350) 2213228..2214076 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
LVJ75_RS10360 (LVJ75_10355) 2214039..2215484 - 1446 WP_003899115.1 APC family permease -
LVJ75_RS10365 (LVJ75_10360) 2215663..2216349 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
LVJ75_RS10370 (LVJ75_10365) 2216540..2217508 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
LVJ75_RS10375 (LVJ75_10370) 2217733..2218152 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ75_RS10380 (LVJ75_10375) 2218161..2218421 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ75_RS10385 (LVJ75_10380) 2218564..2220240 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
LVJ75_RS10390 (LVJ75_10385) 2220228..2220881 - 654 WP_003409976.1 cutinase Cfp21 -
LVJ75_RS10395 (LVJ75_10390) 2220996..2221226 + 231 WP_003409980.1 DUF167 domain-containing protein -
LVJ75_RS10400 (LVJ75_10395) 2221311..2222222 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
LVJ75_RS10405 (LVJ75_10400) 2222331..2222930 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T229177 WP_003409958.1 NZ_CP089780:c2218152-2217733 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T229177 NZ_CP124410:c2500130-2500023 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT229177 WP_003409968.1 NZ_CP089780:c2218421-2218161 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT229177 NZ_CP124410:2500187-2500244 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References