Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2191505..2192049 | Replicon | chromosome |
| Accession | NZ_CP089780 | ||
| Organism | Mycobacterium tuberculosis strain M0003941-3 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | LVJ75_RS10220 | Protein ID | WP_003409896.1 |
| Coordinates | 2191505..2191801 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | LVJ75_RS10225 | Protein ID | WP_070891338.1 |
| Coordinates | 2191798..2192049 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LVJ75_RS10165 (LVJ75_10165) | 2186538..2186888 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| LVJ75_RS10170 (LVJ75_10170) | 2186899..2187801 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| LVJ75_RS10175 (LVJ75_10175) | 2187822..2188013 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| LVJ75_RS10180 (LVJ75_10180) | 2188014..2188310 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| LVJ75_RS10185 (LVJ75_10185) | 2188550..2188765 | + | 216 | WP_003409878.1 | antitoxin | - |
| LVJ75_RS10190 (LVJ75_10190) | 2188762..2189073 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ75_RS10195 (LVJ75_10195) | 2189047..2189568 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| LVJ75_RS10200 (LVJ75_10200) | 2189543..2189920 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| LVJ75_RS10205 (LVJ75_10205) | 2189962..2190411 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| LVJ75_RS10210 (LVJ75_10210) | 2190408..2190953 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| LVJ75_RS10215 (LVJ75_10215) | 2190842..2191456 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| LVJ75_RS10220 (LVJ75_10220) | 2191505..2191801 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LVJ75_RS10225 (LVJ75_10225) | 2191798..2192049 | - | 252 | WP_070891338.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| LVJ75_RS10230 (LVJ75_10230) | 2192036..2192530 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| LVJ75_RS10235 (LVJ75_10235) | 2192690..2193097 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| LVJ75_RS10240 (LVJ75_10240) | 2193101..2193373 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| LVJ75_RS10245 (LVJ75_10245) | 2193406..2194626 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| LVJ75_RS10250 (LVJ75_10250) | 2195525..2196322 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T229176 WP_003409896.1 NZ_CP089780:c2191801-2191505 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T229176 NZ_CP124410:c2397632-2397105 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9193.14 Da Isoelectric Point: 7.0150
>AT229176 WP_070891338.1 NZ_CP089780:c2192049-2191798 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSAVRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSAVRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT229176 NZ_CP124410:c2397905-2397639 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|