229173

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1963542..1964002 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag LVJ75_RS09160 Protein ID WP_003898996.1
Coordinates 1963754..1964002 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag LVJ75_RS09155 Protein ID WP_003408528.1
Coordinates 1963542..1963754 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS09140 (LVJ75_09135) 1960020..1961207 - 1188 WP_003898992.1 nitrate transporter NarK -
LVJ75_RS09145 (LVJ75_09140) 1961494..1961778 + 285 WP_003408522.1 DUF1876 domain-containing protein -
LVJ75_RS09150 (LVJ75_09145) 1961792..1963474 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
LVJ75_RS09155 (LVJ75_09150) 1963542..1963754 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LVJ75_RS09160 (LVJ75_09155) 1963754..1964002 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ75_RS09165 (LVJ75_09160) 1964010..1964747 + 738 WP_003898997.1 hypothetical protein -
LVJ75_RS09170 (LVJ75_09165) 1964841..1966541 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
LVJ75_RS09175 (LVJ75_09170) 1966826..1967227 - 402 WP_003408538.1 hypothetical protein -
LVJ75_RS09180 (LVJ75_09175) 1967217..1967828 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T229173 WP_003898996.1 NZ_CP089780:1963754-1964002 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T229173 NZ_CP124410:1864706-1865083 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT229173 WP_003408528.1 NZ_CP089780:1963542-1963754 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT229173 NZ_CP124410:1864249-1864617 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References