229172

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1942718..1943331 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag LVJ75_RS09045 Protein ID WP_003408465.1
Coordinates 1942718..1943107 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag LVJ75_RS09050 Protein ID WP_003408469.1
Coordinates 1943104..1943331 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS09010 (LVJ75_09005) 1938347..1939261 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
LVJ75_RS09015 (LVJ75_09010) 1939264..1940094 + 831 WP_003408448.1 cyclase family protein -
LVJ75_RS09020 (LVJ75_09015) 1940094..1940444 + 351 WP_003898986.1 cupin domain-containing protein -
LVJ75_RS09025 (LVJ75_09020) 1940497..1941315 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
LVJ75_RS09030 (LVJ75_09025) 1941329..1942108 + 780 WP_003408460.1 IclR family transcriptional regulator -
LVJ75_RS09040 (LVJ75_09035) 1942539..1942670 + 132 Protein_1783 IS3 family transposase -
LVJ75_RS09045 (LVJ75_09040) 1942718..1943107 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
LVJ75_RS09050 (LVJ75_09045) 1943104..1943331 - 228 WP_003408469.1 antitoxin Antitoxin
LVJ75_RS09055 (LVJ75_09050) 1943549..1945033 + 1485 WP_003408473.1 biotin carboxylase -
LVJ75_RS09060 (LVJ75_09055) 1945030..1946277 + 1248 WP_003408476.1 serine hydrolase -
LVJ75_RS09065 (LVJ75_09060) 1946320..1946739 - 420 WP_003408483.1 hypothetical protein -
LVJ75_RS09070 (LVJ75_09065) 1946729..1947439 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T229172 WP_003408465.1 NZ_CP089780:c1943107-1942718 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T229172 NZ_CP124410:c1719743-1719336 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT229172 WP_003408469.1 NZ_CP089780:c1943331-1943104 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT229172 NZ_CP124410:c1719990-1719724 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References