Detailed information of TA system TA022917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2403000..2403583
• Replicon: chromosome
• Accession: NC_010814
• Organism: Geobacter lovleyi SZ

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GLOV_RS19290
• Protein ID: WP_012470303.1
• Coordinates: 2403329..2403583 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B3E4N0
• Locus tag: GLOV_RS11170
• Protein ID: WP_012470302.1
• Coordinates: 2403000..2403332 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GLOV_RS11145	2398960..2399508	+	549	WP_012470300.1	GAF domain-containing protein	-
GLOV_RS11155	2399904..2400881	-	978	WP_012470301.1	integron integrase	-
GLOV_RS19645	2401044..2401403	+	360	WP_153304678.1	hypothetical protein	-
GLOV_RS19650	2401554..2401955	+	402	WP_153304679.1	hypothetical protein	-
GLOV_RS19655	2402087..2402488	+	402	WP_153304680.1	hypothetical protein	-
GLOV_RS11170	2403000..2403332	-	333	WP_012470302.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GLOV_RS19290	2403329..2403583	-	255	WP_012470303.1	type II toxin-antitoxin system HicA family toxin	Toxin
GLOV_RS19660	2403801..2404160	+	360	WP_153304678.1	hypothetical protein	-
GLOV_RS19665	2405358..2405726	+	369	WP_153304681.1	hypothetical protein	-
GLOV_RS19295	2406255..2406488	+	234	WP_012470306.1	(2Fe-2S)-binding protein	-
GLOV_RS11175	2406666..2408180	+	1515	WP_012468113.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-73)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9341.71 Da
• Isoelectric Point: 10.6538

>T22917 WP_012470303.1 NC_010814:c2403583-2403329 [Geobacter lovleyi SZ]
MNNKHRKTLDAIFTEPALSNIAWSDIESLLLAVGAQRFEGNGSRVRFLLNDVKATFHRPHPQKETDKGAVVSVKRFLEAG
GIKP

Nucleotide

• Length: 255 bp

>T22917 NC_010814:c2403583-2403329 [Geobacter lovleyi SZ]
ATGAACAACAAACACCGTAAAACATTAGATGCAATATTCACTGAGCCAGCTCTTTCAAATATTGCATGGTCTGACATTGA
GTCGTTGCTTCTGGCCGTAGGCGCACAAAGGTTTGAAGGCAATGGCTCACGAGTACGGTTTTTGTTGAATGATGTCAAAG
CCACCTTTCACCGACCACATCCGCAAAAGGAAACAGACAAAGGTGCAGTCGTTTCAGTCAAAAGGTTTCTTGAAGCAGGA
GGTATAAAGCCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12656.34 Da
• Isoelectric Point: 5.5455

>AT22917 WP_012470302.1 NC_010814:c2403332-2403000 [Geobacter lovleyi SZ]
MMEYKGYIGKVEFDDEAEIFHGEVINTRDVITFQGTTVAEIKQAFHDSVEDYLDFCAQLGHEPEKPFTGKFMVRIPPDLH
RRIYSSARIAGKSMNAWVVEQLKQSTAYVH

Nucleotide

• Length: 333 bp

>AT22917 NC_010814:c2403332-2403000 [Geobacter lovleyi SZ]
ATGATGGAATATAAAGGATATATTGGCAAAGTTGAGTTTGATGATGAAGCAGAAATTTTCCACGGTGAAGTAATTAACAC
CCGTGACGTAATAACATTTCAGGGGACCACAGTAGCCGAAATAAAACAGGCTTTTCATGATTCCGTAGAAGACTATCTCG
ATTTCTGCGCTCAATTGGGCCATGAACCAGAAAAACCGTTTACCGGCAAGTTCATGGTTCGTATTCCGCCTGACCTCCAC
CGTAGGATTTATTCTTCTGCACGTATTGCCGGGAAAAGCATGAATGCCTGGGTGGTAGAGCAACTAAAACAATCTACCGC
ATACGTACATTAG

Structures

Antitoxin

• AlphaFold DB: B3E4N0