229168

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1541441..1542491 Replicon chromosome
Accession NZ_CP089780
Organism Mycobacterium tuberculosis strain M0003941-3

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag LVJ75_RS07285 Protein ID WP_003407164.1
Coordinates 1541441..1542262 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag LVJ75_RS07290 Protein ID WP_003407167.1
Coordinates 1542255..1542491 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVJ75_RS07265 (LVJ75_07255) 1536999..1537661 - 663 WP_003407152.1 membrane protein -
LVJ75_RS07270 (LVJ75_07260) 1537658..1538443 - 786 WP_003407157.1 membrane protein -
LVJ75_RS07275 (LVJ75_07265) 1538734..1540695 - 1962 WP_003407159.1 sigma-F factor regulator -
LVJ75_RS07280 (LVJ75_07270) 1540834..1541220 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
LVJ75_RS07285 (LVJ75_07275) 1541441..1542262 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
LVJ75_RS07290 (LVJ75_07280) 1542255..1542491 + 237 WP_003407167.1 hypothetical protein Antitoxin
LVJ75_RS07295 (LVJ75_07285) 1542563..1543768 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
LVJ75_RS07300 (LVJ75_07290) 1544071..1544856 + 786 WP_003902048.1 lipoprotein LprF -
LVJ75_RS07305 (LVJ75_07295) 1545052..1545666 + 615 Protein_1438 cytochrome b5-like heme/steroid binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T229168 WP_003407164.1 NZ_CP089780:1541441-1542262 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T229168 NZ_CP124410:c521477-521375 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT229168 WP_003407167.1 NZ_CP089780:1542255-1542491 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT229168 NZ_CP124410:521337-521605 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References